摘要
为考察茶多酚EGCG(表没食子儿茶素没食子酸酯)的不稳定特性,试验设定43℃,25℃,4℃三个不同温度条件,分别以丁二醇、甘油、丙二醇、PEG400四种多元醇为溶剂,以20天为期限,考察温度和溶剂因素对EGCG不稳定性的影响。结果显示:不同种类的溶剂,同一溶剂的不同百分比,以及不同温度条件都会对EGCG的降解产生一定的影响。几种溶剂中60%丁二醇对EGCG的稳定作用相对最好,高温43℃,20天,EGCG降解26.5%;体系中高比例的丁二醇和低温条件对EGCG的降解有一定的缓解保护作用;茶多酚EGCG对试验所选温度、溶剂表现出较差的稳定性,因此含有茶多酚EGCG类成分的原料,直接添加于含水含醇体系的配方可能有降解失效的风险。独立包装,临配现用,纳米包裹等新技术方法应是该类原料更合理的配方应用形式。
In order to investigate the unstable properties of polyphenol EGCG(epigallocatechin gallate),three different temperature conditions,43℃,25℃,4℃,four kinds of solvent,butanediol,glycerol,propylene glycol,PEG400 were tested,respectively.The effect of temperature and solvent factors on the instability of EGCG was investigated over a period of 20 days.The results show that different kinds of solvents,different percentages of the solvents,and different temperature conditions all will have a certain impact on the degradation of EGCG.Among these solvents,60%butanediol has the best stability to EGCG.At high temperature of 43℃,20 days,EGCG degraded by 26.5%.The butanediol was used as a solvent,the high proportion of butanediol and low temperature conditions in the system have a certain effect on the degradation of EGCG;Polyphenol EGCG exhibits poor stability to the temperature and solvent selected for the test.Therefore,the raw material containing the tea polyphenol EGCG component may have the risk of degradation by added to the aqueous alcohol-containing system directly.Independent packaging,ready-to-use,and nano-packages should be a more rational formulation for this type of raw materials.
作者
张营
刘丹
杨娜
程康
Zhang Ying;Liu Dan;Yang Na;Cheng Kang(Shanghai Inoherb Cosmetics Co.,Ltd.,Shanghai 200071,China)
出处
《广东化工》
CAS
2019年第13期54-55,67,共3页
Guangdong Chemical Industry
关键词
茶多酚EGCG
稳定性
配方应用
tea polyphenol EGCG
instability
formulation application
