摘要
目的探讨氨溴索静脉注射、布地奈德雾化联合头孢泊肟酯颗粒治疗小儿肺炎的临床效果。方法选取2017年11月~2018年11月我院收治的60例肺炎患儿作为研究对象,按照随机数字表法分为对照组(30例)和观察组(30例)。对照组采用常规治疗+氨溴索静脉注射+布地奈德雾化治疗,并静脉滴注头孢美唑,观察组采用常规治疗+氨溴索静脉注射+布地奈德雾化治疗,并口服头孢泊肟酯颗粒。比较两组的临床治疗效果、症状体征消失时间、血清白细胞介素-6(IL-6)、降钙素原(PCT)、CD4^+、CD8^+、CD4^+/CD8^+水平和不良反应发生情况。结果观察组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);观察组的肺啰音、发热、咳嗽消失时间短于对照组,差异均有统计学意义(P<0.05);观察组治疗后的IL-6及PCT水平低于对照组,差异均有统计学意义(P<0.05);观察组治疗后的CD8^+低于对照组,CD4^+、CD4^+/CD8^+水平高于对照组,差异均有统计学意义(P<0.05)。结论小儿肺炎采用氨溴索、布地奈德联合头孢泊肟酯颗粒治疗,效果显著,能缩短症状体征的消失时间,有效改善机体的炎症反应,调节免疫系统,具有临床推广应用价值。
Objective To explore the clinical effect of Ambroxol Intravenous Injection,Budesonide Atomization combined with Cefpodoxime Ester Granules in the treatment of infantile pneumonia.Methods Sixty children with pneumonia admitted to our hospital from November 2017 to November 2018 were selected as the research objects,they were divided into control group (30 cases) and observation group (30 cases) according to random number table method.The control group was treated with routine treatment+Ambroxol Intravenous Injection+Budesonide Atomization therapy,and intravenous drip of Cefmetazole.The observation group was treated with routine treatment + Ambroxol Intravenous Injection + Budesonide Atomization therapy,and oral administration of Cefpodoxime Ester Granules.The clinical effect,disappearance time of symptoms and signs,serum levels of interleukin-6 (IL-6),procalcitonin (PCT),CD4^+,CD8^+,CD4^+/CD8^+ and adverse reactions were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,the difference was significant (P<0.05).The disappearance time of lung rale,fever and cough in the observation group were shorter than those in the control group,the differences were statistically significant (P<0.05).After treatment,the levels of IL-6 and PCT in the observation group were lower than those in the control group,the differences were statistically significant (P<0.05).After treatment,the levels of CD8^+ in the observation group were lower than those in the control group,and the levels of CD4^+,CD4^+/CD8^+ in the observation group were higher than those in the control group,the differences were statistically significant (P<0.05).Conclusion Children′s pneumonia is treated with Ambroxol,Budesonide and Cefpodoxime Ester Granules,the effect is remarkable,it can shorten the disappearance time of symptoms and signs,effectively improve the body′s inflammatory response and regulate the immune system.It has clinical application value.
作者
梁波
LIANG Bo(Department of Paediatrics,Longgang Third People′s Hospital of Shenzhen City,Guangdong Province,Shenzhen 518115,China)
出处
《中国当代医药》
2019年第20期70-72,75,共4页
China Modern Medicine
关键词
肺炎
头孢泊肟酯颗粒
小儿
布地奈德
氨溴索
Pneumonia
Cefpodoxime Proxetil Granules
Children
Budesonide
Ambroxol
