摘要
目的 观察氨溴索联合布地奈德雾化吸入治疗新生儿肺炎效果。方法 将66例肺炎患儿按随机数表法分为观察组（n=33）和对照组（n=33）。观察组采用氨溴索联合布地奈德治疗,对照组采用布地奈德治疗。比较2组患儿的肺功能情况、临床效果及血流情况。结果 观察组的总有效率（93.94%）显著高于对照组（45.45%）,2组比较异差异具统计学意义（P〈0.05）;治疗后,2组患儿的一秒用力呼气容积（forced expiratory volume in one second,FEV_1）、呼气峰流速（peak expiratory flow,PEF）较治疗前均有所提高,且观察组的FEV_1、PEF[（95.21±7.69）%、（93.21±7.89）%]明显高于对照组[（87.03±7.23）%、（84.55±7.45）%],2组比较差异具有统计学意义（P〈0.05）;2组患儿的氧指数（oxygen index,OI）较治疗前明显提高,且观察组的OI明显高于对照组,治疗后2组婴儿的动脉血二氧化碳分压（PaCO_2）均明显下降且观察组显著低于对照组,2组比较差异具有统计学意义（P〈0.05）。结论氨溴索药联合布地奈德药治疗新生儿肺炎的疗效显著,可有效的改善婴儿肺功能,缩短治疗时间,同时也有效的改善婴儿的血流动力学。
Objective To observe the effect of aerosol inhalation of ambroxol combined with budesonide on neonatal pneumonia .Methods 66 infants with pneumonia treated were enrolled in this study.The patients were divided into observation group （ n =33 ） and control group （ n =33 ） according to the random number method.The treatment group were treated with ambroxol combined with budesonide and the control group were treated with budesonide.The two groups of infant lung function, clinical outcomes and blood flow were compared.Results The total effective rate （93.94%） in the observation group was significantly higher than that in the control group （45.45%）, there was significant difference between the two groups （P〈0.05）.After treatment, FEV1 and PEF in the two groups were significantly higher than those before treatment, the observation group [（95.21 ± 7.69）%, （93.21 ±7.89）%] were significantly higher than those of the control group[（87.03 ±7.23）%, （84.55 ±7.45）%], the differences between the two groups were statistically significant （P〈0.05）.The OI of the two groups was significantly higher than that of the control group and the OI of the observation group was significantly higher than that of the control group.PaCO2 of the two groups decreased significantly and the PaCO2 of the observation group was significantly lower than that of the control group, the difference was statistically significant （ P〈0.05 ）.Conclusion The combination of ambroxol and budesonide is effective in the treatment of neonatal pneumonia.It can effectively improve the infant pulmonary function, shorten the treatment time and improve the hemodynamics of infants .
出处
《中国生化药物杂志》
CAS
2017年第3期237-239,共3页
Chinese Journal of Biochemical Pharmaceutics
