摘要
目的:分析宫颈高级别鳞状上皮内病变患者的阴道微生态状况,探讨宫颈高级别鳞状上皮内病变与阴道微生态环境的相关性。方法:选择经病理检查确诊的宫颈高级别鳞状上皮内病变患者200例为观察组,设同期妇科门诊行健康体检的妇女200例为对照组,采集阴道内分泌物样本,采用五联检试剂及革兰氏染色检测阴道内乳酸杆菌、阴道pH值、 H2O2及白细胞酯酶指标,比较两组人群各指标的异同。结果:宫颈高级别病变组中的阴道乳酸杆菌阳性人数占比、H2O2(+)人数占比和白细胞酯酶阳性人数占比分别为47.5%、85%和10%,健康体检组分别为77.5%、99.5%和2%,两组比较,差异均有统计学意义(P<0.05);宫颈高级别病变患者的阴道pH值(4.87±0.267),高于健康体检人群的(4.60±0.180),差异有统计学意义(P<0.05)。结论:宫颈高级别鳞状上皮内病变患者的阴道微生态处于失衡状态,宫颈高级别鳞状上皮内病变与阴道微生态环境有相关性。
Objective Analyzing the vaginal Microecology in the patients with cervical high-grade squamous intraepithelia lesions(HSIL),discussing the correlation between cervical high-grade lesions and vaginal microenvironment.Method 200 cases of cervical high-grade lesions who were diagnosed by pathological examination in our hospital were selected as the observation group.In the same period,200 women in the Department of gynecology clinic were selected as the control group.Collecting the Samples of vaginal secretions,using the five combined reagent and Gram staining to test the vaginal Lactobacillus,vaginal pH, H2O2 and the index of leukocyte esterase.Analyzing and comparing the similarities and differences to each index between the two groups.Results The positive rate of lactobacillus vaginalis and leucocyte esterase in the high grade cervical lesion group were 47.5%、85%和10%,respectively, the health examination group were 77.5%、99.5%和2%,respectively, there was significant difference between the two groups(P<0.05).The vaginal PH value of patients with high grade cervical lesions was(4.87 ±0.267),which was higher than that of healthy people(4.60±0.180),the different was statistically significant(P<0.05).Conclusion The vaginal microecology of the patients in HSIL is unbalanced,so the patiets in HSIL are related to the vaginal microenvironment.
作者
郭桂芝
杨拉
蒙震霞
周媚媚
GUO Gui-zhi;YANG La;MENG Zhen-xia(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Guizhou Medical University,Guiyang 550001,China)
出处
《吉林医学》
CAS
2019年第8期1684-1686,共3页
Jilin Medical Journal
