摘要
目的探讨糖尿病视网膜病变(diabetic retinopathy, DR)患者血清补体C1q肿瘤坏死因子相关蛋白1(complement-C1q tumor necrosis factor-related protein 1, CTRP1)水平变化。方法 DR患者81例,其中非增殖期DR(non-proliferative DR, NPDR)患者46例为NPDR组,增殖期DR(proliferative DR, PDR)患者35例为PDR组,同期单纯2型糖尿病患者47例为糖尿病组,体检健康者44例为对照组,采用ELISA法检测4组血清CTRP1及空腹血糖等生化指标水平,Spearman法分析CTRP1与各指标的相关性,多因素logistic回归分析CTRP1与DR发生的关系。结果糖尿病组CTRP1[(7.29±1.57)μg/L]高于PDR组[(6.45±1.84)μg/L]、NPDR组[(5.86±1.29)μg/L]、对照组[(6.16±1.36)μg/L](P<0.05),PDR组、NPDR组、对照组比较差异无统计学意义(P>0.05);4组空腹血糖、糖化血红蛋白等比较差异有统计学意义(P<0.05),血肌酐等比较差异无统计学意义(P>0.05);NPDR组CTRP1与糖化血红蛋白呈正相关(r=0.305,P=0.039);PDR组CTRP1与空腹血糖呈正相关(r=0.336,P=0.048);多因素logistic回归分析结果显示,在调整年龄、病程等因素后,CTRP1<5.5μg/L是DR发生的危险因素(OR=16.304,95%CI:3.687~72.090,P<0.001)。结论 DR患者血清CTRP1水平降低,CTRP1水平降低是DR发生的危险因素。
Objective To investigate the changes of serum complement C1 q tumor necrosis factor(TNF)-related protein 1(CTRP1) level in patients with diabetic retinopathy(DR). Methods The levels of serum CTRP1, fasting plasma glucose and other biochemical indexes were detected by ELISA in 46 patients with non-proliferative DR(NPDR group), 35 patients with proliferative DR(PDR group), 47 patients with type 2 diabetes mellitus(diabetic group) and 44 healthy volunteers(control group). The correlations between CTRP1 and the biochemical indexes were analyzed by Spearman method, and the relationship of CTRP1 with DR was analyzed by multivariate logistic regression. Results The level of CTRP1 was significantly higher in diabetic group((7.29±1.57) μg/L) than that in PDR group((6.45±1.84) μg/L), NPDR group((5.86±1.29) μg/L) and control group((6.16±1.36) μg/L)(P<0.05), and showed no significant differences among PDR group, NPDR group and control group(P>0.05). The fasting plasma glucose and glycosylated hemoglobin showed significant differences(P<0.05), and serum creatinine showed no significant difference among 4 groups(P>0.05). CTRP1 was positively correlated with glycosylated hemoglobin in NPDR group(r=0.305, P=0.039) and fasting plasma glucose in PDR group(r=0.336, P=0.048). Multivariate logistic regression analysis showed that after adjusting for age and course of disease, CTRP1<5.5 μg/L was the risk factor for DR(OR=16.304, 95%CI: 3.687-72.090, P<0.001). Conclusion Serum CTRP1 is lowly expressed in DR patients, and the decreased CTRP1 level is the risk factor for DR.
作者
徐佳佳
刘杰
张慧娟
XU Jiajia;LIU Jie;ZHANG Huijuan(Department of Endocrinology ,the First Affiliated Hospital of Harbin Medical University ,Harbin 150000,China)
出处
《中华实用诊断与治疗杂志》
2019年第7期685-687,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
黑龙江省自然科学基金(H2016040)
