摘要
目的探讨益生菌联合孟鲁司特钠咀嚼片治疗支气管哮喘伴变应性鼻炎的临床疗效及对患儿外周血Th17/Treg免疫平衡的影响。方法选取医院2017年6月至2018年3月收治的患儿106例,按入院顺序随机分为试验组(给予益生菌联合孟鲁司特钠咀嚼片治疗)和对照组(给予单纯孟鲁司特钠咀嚼片治疗),各53例,疗程均为3个月。结果治疗3个月后,试验组患儿治疗总有效率高于对照组(90.57%比71.70%,P<0.05);两组患儿肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、呼气峰值流速(PEF)]均较治疗前升高(P<0.05),且试验组显著高于对照组(P<0.05);两组患儿血清白细胞介素17(IL-17)、白细胞介素6(IL-6)水平均较治疗前明显降低(P<0.05),白细胞介素10(IL-10)水平较治疗前明显升高(P<0.05),且试验组上述指标变化幅度均大于对照组(P<0.05);两组患儿CD8^+水平均较治疗前明显升高(P<0.05),CD4^+和CD4^+/CD8^+均较治疗前明显降低(P<0.05),且试验组变化幅度较对照组更大(P<0.05);两组患儿腹痛腹泻、恶心呕吐、头晕嗜睡的不良反应发生率比较无显著差异(P>0.05)。结论益生菌联合孟鲁司特钠咀嚼片治疗支气管哮喘伴变应性鼻炎,临床疗效显著,可提高肺功能与免疫功能,且不会加重不良反应。
Objective To investigate the clinical efficacy of probiotics combined with Montelukast Sodium Chewable Tablets in the treatment of bronchial asthma complicated with allergic rhinitis and its effect on Th_17/Treg immune balance in peripheral blood of children patients.Methods Totally 106 children patients with bronchial asthma complicated with allergic rhinitis admitted to our hospital from June 2017 to March 2018 were selected and randomly divided into the experimental group(treated with probiotics combined with Montelukast Sodium Chewable Tablets)and the control group(treated with Montelukast Sodium Chewable Tablets only)according to the order of admission,53 cases in each group.Both groups were treated for 3 months.Results After 3 months of treatment,the total effective rate of the experimental group was higher than that of the control group(90.57%vs.71.70%,P<0.05),the lung function indexes of forced vital capacity(FVC),forced expiratory volume in 1 second(FEV1),peak expiratory flow rate(PEF)in the two groups were higher than those before treatment(P<0.05),and those in the experimental group were more significant than those in the control group(P<0.05).The levels of serum interleukin-17(IL-17)and interleukin-16(IL-6)in the two groups were significantly lower than those before treatment(P<0.05),while the level of interleukin-10(IL-10)in the two groups was significantly higher than that before treatment(P<0.05),and the changes of the above indexes in the experimental group were more significant than those in the control group(P<0.05).The level of CD8+in the two groups was significantly higher than that before treatment(P<0.05),while the levels of CD4^+and CD4^+/CD8^+in the two groups were significantly lower than those before treatment(P<0.05),and the changes in the experimental group were more significant than those in the control group(P<0.05).There was no significant difference in the incidence of abdominal pain,diarrhea,nausea and vomiting,dizziness and sleepiness between the two groups(P>0.05).Conclusion Pro
作者
谭燕萍
李景新
欧晓华
陈锡传
TAN Yanping;LI Jingxin;OU Xiaohua;CHEN Xichuan(Guangning County Hospital of Traditional Chinese Medicine,Zhaoqing,Guangdong,China 526300)
出处
《中国药业》
CAS
2019年第15期64-67,共4页
China Pharmaceuticals
基金
广东省肇庆市科技创新指导类项目[201704031006]
