摘要
目的探讨多发腔隙性脑梗死患者中血清胱抑素C(Cys C)水平与血管性轻度认知障碍(vascular mild cognitive impairment,VaMCI)的关系。方法选取2017年9月—2018年9月秦皇岛市第一医院神经内科诊治的284例多发腔隙性脑梗死患者,分为VaMCI组40例,对照组(即认知正常)244例,对二组患者Cys C浓度进行比较分析,应用Logistic回归分析多发腔隙性脑梗死患者患VaMCI的危险因素,采用Pearson直线性分析Cys C与认知功能的相关性。结果在多发腔隙性脑梗死患者中,二组间单因素分析得出年龄、Cys C、空腹静脉血糖、同型半胱氨酸、胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、载脂蛋白A1、载脂蛋白B、受教育程度、高血压病、糖尿病差异有统计学意义(P<0.05)。取二组间单因素分析中差异有统计学意义的变量采用Logistic回归分析进行筛选:得出Cys C、空腹静脉血糖、胆固醇、受教育程度、高血压病、糖尿病是VaMCI的危险因素(P<0.05)。并对Cys C与蒙特利尔认知评估量表(Montreal cognitive assement,MoCA)评分进行Pearson相关性分析,差异有统计学意义(r=-0.301,P<0.05),两者呈负相关。结论多发腔隙性脑梗死患者的高水平Cys C是VaMCI的独立危险因素,可以预测多发腔隙性脑梗死患者早期轻度认知障碍损害,并且Cys C水平越高,认知功能受损越严重,以利于及早诊断及针对性治疗以预防血管性痴呆。
Objective To investigate the relationship between serum cystine C(Cys C)and vascular mild cognitive impairment(vascular mild cognitive impairment,VaMCI)in patients with multiple lacunar infarction.Methods From September 2017 to September 2018,two hundred and eighty-four patients with multiple lacunar cerebral infraction in Department of Neurology under First Hospital of Qinhuangdao were divided into VaMCI group(40 cases)and control group(244 cases).The levels of Cys C in two groups were compared and analyzed.Logistc regression was used to analyze the risk factors of VaMCI in patients with multiple lacunar infarction.Pearson linear analysis was used to analyze the correlation between Cys C and cognitive function.Results In patients with multiple lacunar infarction,univariate analysis between the two groups showed that age,Cys C,fasting venous blood sugar,homocysteine,cholesterol,low density lipoprotein cholesterol,high density lipoprotein cholesterol,apolipoprotein A1,apolipoprotein B,education level,hypertension and diabetes had significant differences(P<0.05).Logistic regression analysis was used to screen the variables with statistical significance in univariate analysis between the two groups.It was concluded that Cys C,fasting venous blood sugar,cholesterol,education level,hypertension and diabetes were risk factors for VaMCI(P<0.05).Pearson correlation analysis of Cys C and MoCA score showed that the difference was statistically significant(r=0.301,P<0.05),the two were negatively correlated.Conclusion High level of Cys C in patients with multiple lacunar infraction is an independent risk factor for VaMCI.It can predict early mild cognitive impairment in patients with multiple lacunar infraction.The higher the level of Cys C,the more severe the cognitive impairment,which is beneficial to early diagnosis and targeted treatment to prevent vascular dementia.
作者
尹博文
尹立勇
吴磊
汪洋
张海垠
郭明伟
黄玉哲
Yin Bowen;Yin Liyong;Wu Lei(Department of Neurology,First Hospital of Qinhuangdao,Qinhuangdao 066000,China)
出处
《中国煤炭工业医学杂志》
2019年第3期258-262,共5页
Chinese Journal of Coal Industry Medicine
基金
河北省卫生与计划生育委员会2018年度医学科学研究重点课题计划(编号:20181190)
河北省高等学校科学技术研究青年基金项目(编号:QN2015180)
