摘要
目的：探索老年腔隙性脑梗死（ LI）患者与认知功能障碍的相关性。方法收集住院LI患者94例，根据头部MR检查将基底节、丘脑区LI的数目分为3组，分别为1～3个为轻度组，4～6个为中度组，≥7个为重度组；另选取头部MR正常的老年人为对照组。以蒙特利尔认知功能评估量表（ MoCA）（北京版）和阿尔茨海默病—认知分表（ ADAS-cog）作为认知评估工具，观察LI各组与对照组相比认知功能是否下降。结果与对照组比较，轻、中度组LI患者认知功能无明显下降（ P ＞0祆．05），重度组LI患者认知功能显著下降（ P ＜0．05）；MoCA总分随着LI分组级别增高呈下降趋势。在ADAS-Cog量表评分中，与对照组比较，轻、中度组LI患者认知功能无明显下降（ P ＞0．05），重度组LI患者认知功能显著下降（ P ＜0．05）；总分随着LI严重增高呈上升趋势。结论认知功能下降越明显。基底节、丘脑区多发性LI影响患者的认知功能，老年LI越严重，认知域主要表现在执行功能、抽象思维、语言功能、注意力、定向力，而对记忆功能影响不明显。
Objective To explore the relationship between lacunar infarction（ LI） and cognitive function.Methods 94 cases of hospitalized patients with LI were collected, according to the MR examination’ s number of basal ganglia and thala-mus’ LI, patients were divided into 3 groups, 1-3 lesions was mild group, 4-6 lesions was moderate group,≥7 lesions was severe group.Select another group of elderly people with normal MR as the control group.The Montreal cognitive assessment scale table （ MoCA） （ Beijing version） and Alzheimer＇s disease cognitive table （ ADAS-Cog） as a cognitive assessment tool to observe different LI group whether has decline in cognitive function.Results Compared with the control group, mild and moderate LI groups had no significantly decrease of cognitive function （ P 〉0.05） , severe LI group’ s cognitive function were decreased significantly （ P 〈0.05）;MoCA scores decreased with the rising of LI group level.In the ADAS-Cog table score, compared with the control group, mild and moderate LI groups ’ cognitive function had no decreased significantly （ P 〉0.05）, severe LI groups’ cognitive function decreased significantly （ P 〈0.05）;the total score increased with the rising of LI grouping level.The more serious of the LI of the basal ganglia and the thalamus in the thalamus, the more obvious of the decrease of the cognitive function.Conclusion Basal ganglia and thalamus area multiple LI influence patients cognitive func-tion, cognitive domain is mainly manifested in the execution of the function, abstract thinking, language function, attention, orientation, and influence on memory function is not obvious.
出处
《疑难病杂志》
CAS
2015年第7期679-681,共3页
Chinese Journal of Difficult and Complicated Cases
基金
黑龙江省自然科学基金资助项目(No.D201143)
关键词
腔隙性脑梗死
认知功能
基底节
丘脑
执行功能
Lacunar infarction
Cognitive function
Basal ganglia
Thalamus
Executive function
