摘要
目的探究不同剂量尼莫地平注射液防治蛛网膜下腔出血(SAH)后脑血管痉挛(CVS)的效果。方法选取120例SAH患者为受试对象,随机数字表法分为小剂量组(0.2~0.4mg/h)、中剂量组(0.5~0.8mg/h)及大剂量组(1~2mg/h)各40例。比较所有患者治疗前及治疗14d后大脑各大动脉的收缩峰速度、脑脊液中内皮素-1(ET-1)与一氧化氮(NO)水平,并记录其CVS发生率。结果治疗14d后,3组患者的PCA的收缩峰速度较治疗前均显著下降(P<0.05),3组之间比较无统计学意义(P>0.05);而中剂量组及大剂量组的MCA及ACA的收缩峰速度、脑脊液中的ET-1水平较治疗前显著下降(P<0.05),且两者之间比较无统计学意义(P>0.05);而3组的NO水平及小剂量组治疗前后ET-1及NO水平变化无统计学意义(P>0.05);小剂量组CVS发生率为27.5%,中剂量组为7.5%,大剂量组为5%,其中中、大剂量组之间无统计学意义(P>0.05),且明显低于小剂量组(P<0.05)。结论大剂量的尼莫地平注射液对防治SAH后CVS效果最佳。
Objective To investigate the effect of different doses of nimodipine injection on prevention and treatment of cerebral vasospasm(CVS)after subarachnoid hemorrhage(SAH).Methods A total of 120 SAH patients who were treated were enrolled.The randomized digital table was used to divide them into low-dose group(0.2-0.4 mg/h)and medium-dose group(0.5-0.8 mg/h)and the high-dose group(1-2 mg/h),40 cases each.The systolic peak velocity,endothelin-1(ET-1)and nitric oxide(NO)levels in the cerebrospinal fluid of all the brains before and after treatment were compared,and the incidence of CVS was recorded.Results After 14 days of treatment,the systolic peak velocity of PCA in the three groups was significantly lower than that before treatment(P<0.05).There was no significant difference among the three groups(P>0.05).The systolic peak velocity and ET-1 level in cerebrospinal fluid of MCA and ACA in the middle dose group and the high dose group were significantly lower than those before treatment(P<0.05),and there was no significant difference between the two groups(P>0.05).There was no significant difference in NO levels between the 3 groups(P>0.05).There was no significant difference in ET-1 and NO levels between the low-dose group before and after treatment(P>0.05).The incidence of CVS was 11/40(27.5%)in the low-dose group,3/40(7.5%)in the middle-dose group,and 2/40(5%)in the high-dose group.There was no statistical difference between the medium and high-dose groups(P>0.05),and significantly lower than the low-dose group(P<0.05).Conclusion High-dose nimodipine injection has the best effect on CVS after SAH.
作者
付艳红
周鹏
Fu Yanhong;Zhou Peng(Chinese Medicine Hospital of Sui County,Brain Department Ward One,Shangqiu 476900,China)
出处
《哈尔滨医药》
2020年第5期403-405,共3页
Harbin Medical Journal
关键词
尼莫地平
预防
效果
脑血管痉挛
蛛网膜下腔出血
Nimodipine
Prevention
Effect
Cerebral vasospasm
Subarachnoid hemorrhage
