摘要
随着骨组织工程技术的快速发展,已能够成功制备不同种类人工支架材料用于骨缺损的修复。因孔状支架材料可以有效模拟细胞外基质(extracellular matrix,ECM)微环境,能够有效促进组织生长、血管形成、营养物质和代谢产物的交换,在骨组织工程领域具有广阔的应用前景。近年来,因基于石墨烯的三维(3D)复合支架具有良好的生物相容性、机械性能、大的比表面积和出色的骨传导/诱导性能等众多优点,成为了骨组织工程领域的研究热点。因此,本文就3D石墨烯支架的制备方法以及石墨烯复合支架在骨组织工程领域现有的研究成果做一系统性回顾和分析。
With the rapid development of bone tissue engineering technology, different kinds of artificial scaffold have been successfully prepared for the repair of bone defects. The macro-porous scaffolds can effectively simulate the extracellular matrix (ECM) microenvironment, further promote the exchange of nutrients and metabolites, growth of tissue, and angiogenesis. It has a promising prospect in the field of bone tissue engineering. In recent years, the three-dimensional (3D) graphene-based composite scaffolds have become a research hotspot in the field of bone tissue engineering due to their large specific surface area, excellent biocompatibility, mechanical properties, and osteoconductivity. Therefore, this paper systematically reviewed and analyzed the preparation methods of 3D graphene scaffolds and the application of graphene-based composite scaffolds in the field of bone tissue engineering.
作者
刘斌
宋付祥
LIU Bin;SONG Fuxiang(School and Hospital of Stomatology, Lanzhou University, Lanzhou 730000, China)
出处
《口腔医学研究》
CAS
北大核心
2019年第7期619-624,共6页
Journal of Oral Science Research
关键词
三维
石墨烯
制备
骨组织工程
three-dimensional
graphene
preparation
bone tissue engineering
