摘要
树突状细胞(DC)是目前所知体内最强的专职抗原提呈细胞,系连接固有免疫与适应性免疫的主要桥梁。新近的研究提示,生物材料对DC免疫功能的效应是决定生物材料发挥作用的重要因素。本文重点介绍生物材料物理化学特性对DC免疫功能的影响及其受体途径、信号通路,为深入理解生物材料与机体免疫系统的相互作用提供理论依据,并为生物材料的设计及选择开辟新途径。
Dendritic cells(DC)are the most potent antigen-presenting cells(APC)that can activate naive T cell and bridge innate and adaptive immunity.Recently,the potential interaction of DC with biomaterials appears to be to some extent critical for exerting the function of biomaterials.Herein we summarized the effects of physical as well as chemical properties of biomaterials on the immune function of DC together with their receptor and signaling pathway.This review might provide a fully understanding of the interaction of DC with biomaterials,and a new idea for the design and selection of biomaterials.
作者
朱富军
童亚林
盛志勇
姚咏明
ZHU Fu-Jun;TONG Ya-Lin;SHENG Zhi-Yong;YAO Yong-Ming(Trauma Research Center, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China;Department of Burns,Plastic and Wound repair surgery,the 181st Hospital of Chinese PLA, Guilin 541002, China)
出处
《生理科学进展》
CAS
CSCD
北大核心
2018年第6期411-417,共7页
Progress in Physiological Sciences
基金
国家自然科学基金重点项目(81730057)
国家重点研发计划项目(2017YFC1103302)
漓江学者专项基金资助课题
关键词
生物材料
树突状细胞
免疫功能
受体
信号通路
biomaterials
dendritic cells
immune function
receptors
signaling pathway
