摘要
运用骨组织工程技术修复骨缺损是近年来研究的热点,其中对骨组织工程技术中关键要素之一的骨修复材料的研究最为深入。纳米TCP(nano-TCP)/可吸收高聚物复合材料因其优良的骨传导性、骨生成性及骨诱导性而备受关注,但由于nano-TCP颗粒团聚而引起的复合材料性能的恶化仍然是当下研究的难点。本文从nano-TCP颗粒分散性的研究意义、团聚原理以及改善分散性的方法3个方面进行文献综述与讨论,期望为进一步改善nano-TCP/可吸收高聚物复合材料的应用性能提供参考。
The use of bone tissue engineering technology to repair bone defects has been a hot topic in recent years. Among them, the research on bone repair materials, one of the key elements in bone tissue engineering technology, is the most in-depth. nano-TCP/absorbable polymer composites have attracted much attention due to their excellent osteoconductivity,osteogenicity and osteoinductivity. However, the deterioration of composite properties due to agglomeration of nano-TCP particles is still a difficult point in current research. This paper reviews and discusses the research significance of nanoTCP particle dispersibility, the mechanism of agglomeration and the method of improving dispersibility. It is expected to provide reference for further improving the application performance of nano-TCP/absorbable polymer composites.
作者
刘来俊
张天添
丁雯
王富军
王璐
Liu Layun;Zhang Tiantian;Ding Wen(Key Laboratory of Textile Science & Technology, Ministry of Education, College of Textiles, Donghua University, Shanghai, 201620, China)
出处
《生物骨科材料与临床研究》
CAS
2019年第3期63-66,70,共5页
Orthopaedic Biomechanics Materials and Clinical Study
基金
“111计划”(b07024)
中央高校基本科研基金(2232015a3-02和16d110119)
上海市科技支撑计划(16441903803)
国家博士后基金(2016m590299)
