摘要
目的探讨五灵丸联合注射用丁二磺酸腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症的临床疗效。方法选取2017年10月-2018年10月广州市番禺区中心医院收治的120例妊娠期肝内胆汁淤积症患者作为研究对象,将患者随机分为对照组和治疗组,每组各60例。对照组患者静脉滴注注射用丁二磺酸腺苷蛋氨酸,1g溶于250m L生理盐水进行稀释,1次/d;治疗组患者在对照组基础上口服五灵丸,9g/次,3次/d,两组患者均连续治疗14d。观察两组患者的临床疗效,同时比较两组的Ribalta评分、肝功能指标和妊娠结局。结果治疗后,对照组和治疗组的总有效率分别为76.67%、93.33%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者Ribalta评分均明显降低,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,治疗组Ribalta评分明显低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)、结合胆红素(DBiL)和碱性磷酸酶(ALP)水平均显著降低,同组治疗前后比较差异具有统计学意义(P<0.05);治疗后,治疗组肝功能指标水平显著低于对照组,两组比较差异具有统计学意义(P<0.05)。治疗后,治疗组胎儿窘迫率、早产率、产后出血发生率、剖宫产率显著低于对照组,两组比较差异具有统计学意义(P<0.05)。结论五灵丸联合注射用丁二磺酸腺苷蛋氨酸治疗妊娠期肝内胆汁淤积症具有较好的临床疗效,能显著改善患者的临床症状和肝功能指标,具有一定的临床推广应用价值。
Objective To investigate the curative effect of Wuling Pills combined with Ademetionine 1,4-Butanedisulfonate for injection in treatment of intrahepatic cholestasis of pregnancy. Methods Patients(120 cases) with intrahepatic cholestasis of pregnancy in Guangzhou Panyu Central Hospital from October 2017 to October 2018 were randomly divided into control and treatment groups, and each group had 60 cases. Patients in the control group were iv administered with Ademetionine 1,4-Butanedisulfonate for injection, 1 g dissolved in 250 mL normal saline for dilution, once daily. Patients in the treatment group were po administered with Wuling Pills on the basis of control group, 9 g/time, three times daily. Patients in two groups were treated for 14 d. After treatment, the clinical efficacies were evaluated, and the Ribalta score, liver function indexes, and pregnancy outcome in two groups were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 76.67% and 93.33%, respectively, and there was difference between two groups(P < 0.05). After treatment, the Ribalta scores in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the Ribalta scores in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the levels of ALT, AST, TBIL, DBiL, and ALP in two groups were significantly decreased, and the difference was statistically significant in the same group(P < 0.05). After treatment, the liver function index levels in the treatment group were significantly lower than those in the control group, with significant difference between two groups(P < 0.05). After treatment, the rates of fetal distress, premature delivery, postpartum hemorrhage, and cesarean section in the treatment group were significantly lower than those in the control group, and the difference between two groups was statistically significant
作者
刘育娜
邬瑞霞
黄瑞连
LIU Yu-na;WU Rui-xia;HUANG Rui-lian(Department of Obstetrics and Gynecology, Guangzhou Panyu Central Hospital, Guangzhou 511400, China)
出处
《现代药物与临床》
CAS
2019年第6期1771-1774,共4页
Drugs & Clinic
