摘要
目的观察中西医结合治疗妊娠胆汁淤积症的临床疗效。方法将120例妊娠胆汁淤积症分为对照组与治疗组各60例。对照组采用纯西医手段治疗,治疗组在对照组基础上加用自拟柴胡利黄汤治疗。两组疗程均为14 d。结果治疗组总有效率为93.33%,高于对照组的73.33%(P<0.05)。两组治疗后各项中医症状积分均较治疗前降低(P<0.05);治疗组降低更加明显(P<0.05);两组治疗后总胆汁酸(TBA)、谷草转氨酶(AST)、谷丙转氨酶(ALT)、直接胆红素(DBiL)及甘油酸(CG)水平均较治疗前改善(P<0.05);两组比较,治疗组改善更加明显(P<0.05)。两组治疗后白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)水平均较治疗前改善(P<0.05);治疗组改善更加明显(P<0.05)。治疗组在黄疸消退比例与黄疸消退时间方面均优于对照组(P<0.05)。两组早产率与新生儿体质量差异无统计学意义(P>0.05);羊水污染与产后出血比较,治疗组发生率更低(P<0.05)。结论中西医结合治疗妊娠胆汁淤积症疗效更优,且能改善肝功能,妊娠结局更好。
Objective:To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of cholestasis in pregnancy.Methods:A total of 120 cases of cholestasis in pregnancy were divided into the control group and treatment group,60 cases in each group.The control group was treated with pure west⁃ern medicine,and the treatment group was treated with Self-designed Chaihu Lihuang Decoction on the basis of the control group.The course of treatment in both groups was 14 d.Results:The total effective rate of the treat⁃ment group was higher than that of the control group,the difference was statistically significant(P<0.05).Scores of TCM symptoms in both groups decreased after treatment(P<0.05),and the reduction was more obvious in the treatment group(P<0.05).After treatment,the levels of TBA,AST,ALT,DBiL and CG in the two groups were all improved(P<0.05),and the improvement was more obvious in the treatment group(P<0.05).The levels of IL-4 and IFN-in both groups were improved after treatment(P<0.05),and the improvement was more obvious in the treatment group(P<0.05).The improvement of jaundice after treatment was compared between the two groups,and the results showed that the proportion of jaundice regression and the time of jaundice regression in treatment group were better than those in control group(P<0.05).There was no significant difference between the preterm birth rate and neonatal weight after treatment between the two groups(P>0.05).The incidence of postpartum hem⁃orrhage and amniotic fluid pollution was lower in the treatment group,and the difference was statistically significant(P<0.05).Conclusion:The integrated treatment of traditional Chinese and western medicine for cholestasis in pregnancy is more effective;it can improve liver function and the pregnancy outcome is better.
作者
蔡蕊
刘小英
蒋冬萍
Cai Rui;Liu Xiaoying;Jiang Dongping(North West Wonmen and Children′s Hospital,Shaanxi,Xi′an 710000,China)
出处
《中国中医急症》
2021年第6期1047-1050,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
陕西省重点研发计划一般项目(2020SF-031)。
关键词
妊娠
胆汁淤积综合征
中西医结合
Pregnancy
Cholestasis syndrome
Integrated traditional Chinese and western medicine
