摘要
肝细胞癌(hepatocellular carcinoma,HCC)是全球最常见的肝脏原发性肿瘤,其具有起病隐匿、发病率高、生长迅速、侵袭性强和致死率高等特点,目前尚缺乏有效的治疗手段,因此更好地阐明肝癌发生的分子机制对于开发新的诊断方法以及鉴定新的治疗靶点至关重要。近年来随着高通量测序技术的快速发展,表观遗传修饰尤其是甲基化修饰研究开始得到了重视,人类肿瘤中常见的表观遗传甲基化修饰包括DNA甲基化、组蛋白甲基化及近年来兴起的RNA甲基化。本文就近年来RNA甲基化修饰在HCC领域的相关研究做一综述,为HCC发病机制的研究提供新的方向。
Epigenetics studies how cells affect the genome and produce related phenotypes without involving changes in nuclear DNA sequences. The main manifestation is that different types of genetic material are modified. These dynamic modifications affect gene expression and play an important regulatory role in the development of a variety of diseases, particularly tumors. In recent years, epigenetic modification has more and more new insights in the field of hepatocellular carcinoma. RNA methylation and DNA methylation are closely related to the pathogenesis of hepatocellular carcinoma and malignant transformation. This review aims to introduce the latest research advances in various RNA methylation modifications in the field of hepatocellular carcinoma. The different types of RNA methylation as the main line to introduce their research details in hepatocellular carcinoma provide new insights and ideas for the research and treatment of hepatocellular carcinoma.
作者
金春
李蒙蒙
李余佳
高俪原
梁宝瑜
王桭屹
张峰
邵江娟
郑仕中
JIN Chun;LI Meng-meng;LI Yu-jia;GAO Li-yuan;LIANG Bao-yu;WANG Zhen-yi;ZHANG Feng;SHAO Jiang-juan;ZHENG Shi-zhong(Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing 210023, China;Jiangsu Key Laboratory of Substance of Chinese Medicine, Nanjing 210023, China;State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine, Nanjing 210023, China)
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2019年第7期1339-1344,共6页
Chinese Journal of Pathophysiology
基金
国家自然科学基金资助项目(No.31600653
No.31571455
No.31401210
No.81600483
No.81270514)
江苏省自然科学基金资助项目(No.BK20140955)
江苏省高校自然科学研究面上项目(No.16KJB310010)
江苏省中药药效与安全性评价重点实验室开放课题(No.JKLPSE 201502)
江苏高校优势学科建设工程资助项目(No.PAPD)
关键词
表观遗传修饰
RNA甲基化
肝细胞癌
Epigenetic modification
RNA methylation
Hepatocellular carcinoma
