摘要
目的研究生酮饮食(KD)对难治性癫痫患儿血管内皮功能的影响。方法收集2014年5月至2018年3月在福建医科大学附属协和医院儿内科行KD治疗的14例难治性癫痫患儿的临床资料,检测其治疗前及治疗3个月后的三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、一氧化氮(NO)、内皮素-1(ET-1)和血管性假性血友病因子(vWF)水平,并采用重复测量方差分析进行统计分析。结果1.血脂水平变化:KD治疗3个月后,TG、TC水平轻度升高[(1.08±0.14) mmol/L、(5.19±0.146) mmol/L比(0.97±0.10) mmol/L、(4.57±0.29) mmol/L],HDL水平轻度降低[(1.19±0.08) mmol/L比(1.31±0.08) mmol/L],治疗前后比较差异无统计学意义(均P>0.05);治疗后LDL水平较治疗前升高[(3.73±0.40) mmol/L比(2.93±0.25) mmol/L],差异有统计学意义(P=0.034)。2.血管内皮功能评估:与治疗前比较,KD治疗3个月NO[(60.84±5.29)μmol/L比(66.45±5.39)μmol/L]、ET-1[(1.24±0.30) ng/L比(2.13±0.78) ng/L]和vWF[(150.53±12.97)μg/L比(137.57±13.10)μg/L]水平的变化差异均无统计学意义(均P>0.05)。结论难治性癫痫患儿接受3个月KD治疗后LDL水平升高,但血管内皮功能未见明显变化。
Objective To study the effect of ketogenic diet (KD) on vascular endothelial function in children with intractable epilepsy. Methods Clinical informations of 14 children with intractable epilepsy in Fujian Medical University Affiliated Union Hospital from May 2014 to March 2018 were collected.Their blood index values were tested and retested before and after 3 months of KD treatment, including triglycerides (TG), total cholesterol (TC), high-density lipoprotein (HDL), low density lipoprotein (LDL), nitric oxide (NO), endothelin-1 (ET-1), and von Willebrand factor (vWF). These data were statistically analyzed by using repeated measurement analysis of variance. Results (1)Changes in blood lipid levels: the levels of TG and TC increased slightly [(1.08±0.14) mmol/L,(5.19±0.64) mmol/L vs.(0.97±0.10) mmol/L,(4.57±0.29) mmol/L]and the level of HDL decreased slightly [(1.19±0.08) mmol/L vs.(1.31±0.08) mmol/L]after 3 months of KD treatment, but the differences were not statistically significant in the above indexes (all P>0.05). The level of LDL before KD was significantly lower than that after 3 months of KD [(2.93±0.25) mmol/L vs.(3.73±0.40) mmol/L ], and the difference was statistically signi-ficant(P=0.034).(2)Assessment of vascular endothelial function: compared with before KD, all the levels of NO [(60.84±5.29)μmol/L vs.(66.45±5.39)μmol/L ], ET-1 [(1.24±0.30) ng/L vs.(2.13±0.78)ng/L] and vWF [(150.53±12.97)μg/L vs.(137.57±13.10)μg/L]had no statistically significant changes after 3 months of KD(all P>0.05). Conclusions KD treatment lasting 3 months in children with intractable epilepsy can raise the level of LDL, but can′t change the vascular endothelial function.
作者
陈慧
陈燕惠
郑杰
卢洪珠
Chen Hui;Chen Yanhui;Zheng Jie;Lu Hongzhu(Department of Pediatrics,Fujian Medical University Affiliated Union Hospital,Fuzhou 350001,China Corresponding author:Chen Yanhui,Email:yanhui_0655@126.com)
出处
《中华实用儿科临床杂志》
CSCD
北大核心
2019年第12期915-917,共3页
Chinese Journal of Applied Clinical Pediatrics
基金
福建省卫计委青年项目(2014-1-41).
关键词
生酮饮食
血脂异常
血管内皮功能
难治性癫痫
儿童
Ketogenic diet
Dyslipidemias
Vascular endothelial function
Intractable epilepsy
Child
