摘要
目的探讨成都市血液中心单采血小板献血者血液初筛不合格的原因。方法选择2017年1月至12月于成都市血液中心参加单采血小板献血的36 127例无偿献血者为研究对象。献血者年龄为(32.4±7.7)岁;男性献血者为26 423例,女性为9 704例。单采血小板献血前,采集所有献血者肘正中静脉全血4 mL,用于血液初筛项目检测。检测项目包括丙氨酸转氨酶(ALT)值、血小板计数、血细胞比容(HCT)、白细胞计数(WBC)、血红蛋白(Hb)值,乳糜血和乙型肝炎病毒表面抗原(HBsAg)表达情况。根据《血站技术操作规程(2015版)》,判断单采血小板献血者血液初筛合格情况,并且分别计算献血者的血液初筛总不合格率及各检测项目不合格率。采用χ2检验比较所有献血者血液初筛各检测项目的不合格率,以及男、女性献血者血液初筛各检测项目的不合格率。本研究遵循的程序符合2013年修订的《世界医学协会赫尔辛基宣言》的要求,献血前与献血者均签署《献血者知情同意书》。结果①本研究2017年于成都市血液中心参加单采血小板献血的36 127例无偿献血者中,血液初筛不合格者为19 323例,初筛总不合格率为53.49%。② 19 323例单采血小板献血前血液初筛不合格献血者中,初筛各检测项目的不合格率由高至低依次为HCT(15.82%)、血小板计数(15.45%)、ALT值(9.72%)、WBC(7.60%)、乳糜血(3.96%)、Hb值(0.80%)、HBsAg(0.17%)。血液初筛各检测项目的不合格率总体比较,差异有统计学意义(χ2=12 724.350,P<0.001)。单采血小板献血者血液初筛不合格的主要原因包括HCT降低、ALT值升高和血小板计数降低,该3项指标不合格献血者例数占总不合格献血者的比例为76.63%(14 806/19 323)。③ 19 323例单采血小板献血前血液初筛不合格的献血者中,男性献血者初筛不合格率为40.44%(10 689/26 423),低于女性献血者的89.01%(8 638/9 704),并且差异有统计意义(χ
Objective To analyze the causes of unqualification in primary blood screening among voluntary blood donors of apheresis platelets in Chengdu Blood Center. Methods A total of 36 127 cases of voluntary blood donors who participated in apheresis platelets donation in Chengdu Blood Center from January to December 2017 were selected as study objects. Age of blood donors was (32.4±7.7) years. Male and female blood donors were 26 423 and 9 704 cases, respectively. Before donation of apheresis platelets, about 4 mL of whole blood was taken from the elbow vein of each blood donor, and these whole blood samples were used for the inspection of primary blood screening. Inspection items of primary blood screening included alanine transaminase (ALT) value, platelet count, hematocrit (HCT), white blood cell count (WBC), hemoglobin (Hb) value, chylemia and hepatitis B virus surface antigen (HBsAg) expression. Then, qualification situations for primary blood screening of apheresis platelets donors were assessed according to Technical Operation Procedure for Blood Stations (2015 Edition). Total unqualified rate of primary blood screening in all apheresis platelets donors, and unqualified rates of each inspection item were counted, respectively. Chi-square test was used to compare the unqualified rates of each inspection item of all blood donors, as well as the unqualified rates between the male and female blood donors. The procedures followed in this study were in line with the requirements of the revised Declaration of Helsinki of World Medical Association in 2013. And all blood donors signed Informed Consent of Blood Donors before blood donating. Results ① In this study, among the 36 127 blood donors who participated in apheresis platelets donation in Chengdu Blood Center in 2017, 19 323 cases were unqualified in primary blood screening, and the total unqualified rate of primary blood screening was 53.49%.② Among the 19 323 cases of apheresis platelets donors who were unqualified in primary blood screening, the unqualified
作者
赵颖
杨建英
涂丽梅
Zhao Ying;Yang Jianying;Tu Limei(Chengdu Blood Center, Chengdu 610041, Sichuan Province, China)
出处
《国际输血及血液学杂志》
CAS
2019年第3期201-206,共6页
International Journal of Blood Transfusion and Hematology
关键词
无偿献血者
单采血小板
丙氨酸转氨酶
血小板计数
血细胞比容
血液初筛
不合格
原因分析
招募策略
无偿献血者
Voluntary blood donor
Apheresis platelets
Alanine transaminase
Plantlet count
Hematocrit
Primary blood screening, unqualification
Causes analysis
Recruitment strategy, voluntary blood donors
