摘要
目的探讨山东省东营市街头无偿献血者血液的丙氨酸转氨酶(ALT)不合格报废情况,以及控制街头采血点ALT漏检率的有效措施。方法选择2016年4月至2018年3月于东营市中心血站的城区某街头采血点自愿参加无偿献血的12 415例献血者为研究对象。其中,于2016年4月至2017年3月参加无偿献血的献血者为6 897例,于2017年4月至2018年3月参加无偿献血的献血者为5 518例。献血者血液样本的ALT初检采用干式生化法,ALT复检采用自动生化分析仪速率法。根据献血者ALT初检及复检结果,计算ALT初检漏检率,以及ALT不合格报废率。根据于2016年4月至2017年3月参加无偿献血的6 897例献血者的ALT初检漏检率的分布情况,分析ALT初检漏检的规律。考察ALT初检漏检的规律运用于控制2017年4月至2018年3月街头无偿献血者血液的ALT不合格报废率的效果。不同ALT初检结果区间的漏检率比较采用χ^2检验,不同ALT初检结果区间的漏检献血者构成比比较采用趋势χ^2检验。采血工作人员在献血者献血前,均对其履行书面告知义务,均征得献血者的知情同意,并取得献血者签定的知情同意书。 结果①本研究于2016年4月至2017年3月参加无偿献血的6 897例献血者中,96例献血者的ALT复检结果>50 U/L,ALT初检的总漏检率为1.38%,即该批采血因ALT不合格导致的报废率为1.38%。漏检的96例献血者的初检结果为42 U/L≤ALT值≤50 U/L,并且主要集中分布于47 U/L≤ALT值≤50 U/L,所占比例达77.1%(77/96)。对于ALT初检结果<42 U/L的献血者,无1例漏检,漏检率为0。本研究于2016年4月至2017年3月参加无偿献血的6 897例献血者中,不同ALT初检结果区间内漏检率比较,差异有统计学意义(χ^2=50.64,P<0.001),ALT初检结果由高到低的区间内,献血者的构成比有下降趋势(χ^2趋势=85.00,P<0.001)。②本研究于2017年4月至2018年3月参加无偿献血的5 518献血者中,ALT初检结果为4
Objective To investigate the blood scrapping of unqualified alanine transaminase (ALT) from non-remunerated voluntary blood donors on the streets in Dongying City, Shandong Province, in order to control the ALT undetected error rate of street blood collection points effectively.Methods A total of 12 415 cases blood donors, who volunteered to participate in blood donation on the street in Dongying City from April 2016 to March 2018, were selected as subjects in this study. There were 6 897 cases blood donors who participated in blood donation from April 2016 to March 2017, and 5 518 cases blood donors who participated in blood donation from April 2017 to March 2018. The initial test of ALT in blood samples of blood donors were used dry biochemical method. And the retest of ALT were used kinetic method by automatic biochemical analyzer. According to the results of the initial test and retest of blood samples from blood donors, the initial undetected error rates and scrap rates of unqualified ALT were calculated. According to the distribution of ALT initial undetected error rates of 6 897 cases blood donors who participated in blood donation from April 2016 to March 2017, the rules of ALT initial undetected error was analyzed. And to investigate the effect of control the scrap rate of unqualified ALT of blood collection on the street from April 2017 to March 2018 by the rules of ALT initial undetected errors.Results ① In the study, among the 6 897cases blood donors who participated in blood donation from April 2016 to March 2017, the blood retest results of ALT value from 96 cases blood donors were >50 U/L. The total initial undetected error rate of ALT was 1.38%, and it meant the scrap rate of unqualified ALT was 1.38% too. The initial test results of ALT value in these 96 cases blood donors who undetected in initial test were distributed at the range of 42 U/L≤ALT value≤50 U/L, and mainly concentrated at 47 U/L≤ALT value≤50 U/L, accounting for 77.1%(74/96). For blood donors with the ALT initial test resu
作者
门守山
孟祥磊
明丽丽
张永
张超
Men Shoushan;Meng Xianglei;Ming Lili;Zhang Yong;Zhang Chao(Dongying Central Blood Station,Dongying 25709,Shandong Province,China)
出处
《国际输血及血液学杂志》
CAS
2018年第6期506-510,共5页
International Journal of Blood Transfusion and Hematology
关键词
丙氨酸转氨酶
血液安全
血液报废
血液报废率
街头采血
Alanine transaminase
Blood safety
Blood scrap
Blood scrap rate
Street blood collection
