摘要
目的探讨利拉鲁肽治疗新诊断2型糖尿病患者的有效性及安全性。方法选取2016年4月至2017年4月内分泌科住院的2型糖尿病患者,按照标准纳入患者40例,随机分为试验组和对照组,每组20例。对照组采用口服降糖药物或胰岛素治疗,试验组在此基础上加用利拉鲁肽。治疗6个月后观察试验组和对照组的治疗效果。结果试验组和对照组在进行利拉鲁肽治疗后,空腹血糖、餐后2 h血糖及糖化血红蛋白和治疗前比较均有显著下降(P<0.05),但试验组和对照组差异无统计学意义(P>0.05)。利拉鲁肽组治疗后体重、腹围、BMI值、血脂、总胆固醇指标较治疗前显著降低(P<0.05),且试验组和对照组间差异有统计学意义(P<0.05)。结论利拉鲁肽治疗新诊断2型糖尿病的降糖效果显著,可以降低患者体重,降低血脂、总胆固醇等指标,同时具有良好的安全性。
Objective To investigate the effectiveness and safety of liraglutide in treatment of newly diagnosed type 2 diabetes mellitus.Methods Forty patients with type 2 diabetes mellitus who were diagnosed and treated in department of endocrinology from April 2016 to April 2017 were randomly divided into experimental group(n=40) and control group(n=40).The patients in control group were treated by oral hypoglycemics or insulin,however,the patients in experimental group,on the basis of control group, were treated by liraglutide.After 6-month treatment,the therapeutic effects were observed and compared between two groups.Results After treatment the levels of fasting blood glucose,postprandial 2 h blood glucose and glycated hemoglobin were significantly decreased in both groups, as compared with those before treatment(P<0.05),however,there were no significant differences between the two groups(P>0.05).After treatment,the body weight,abdominal circumference,BMI value,blood lipids,total cholesterol levels in experimental group were significantly decreased,as compared with those before treatment(P<0.05),moreover,there were significant differences between the two groups(P<0.05).Conclusion The liraglutide in treatment of newly diagnosed type 2 diabetes mellitus has significant hypoglycemic effects,which can reduce patient’s body weight,decrease blood lipids,total cholesterol and the other indexes,with good safety.
作者
黄倩
刘婵
黄福常
张玲
李佳芮
王丹
骆雅静
王亚娜
HUANG Qian;LIU Chan;HUANG Fuchang(Department of Endocrinology, Central Hospital of Cangzhou City, Hebei, Cangzhou 061001 ,China)
出处
《河北医药》
CAS
2019年第12期1821-1824,共4页
Hebei Medical Journal
关键词
利拉鲁肽
胰岛素
2型糖尿病
liraglutide
insulin
type 2 diabetes mellitus
