摘要
目的 检测不同胎龄及出生体重早产儿血游离肉碱(FC)浓度,为制定早产儿FC补充治疗方案提供依据。方法 选取3368例早产儿为研究对象。根据胎龄(GA)分为超早产(EPTB,GA<28周)组(n=39)、极早产(VPTB,28≤GA<32周)组(n=405)、中期早产(MPTB,32≤GA<34周)组(n=507)、晚期早产(LPTB,34≤GA<37周)组(n=2417);根据出生体重(BW)分为超低出生体重(ELBW,BW<1000g)组(n=36)、极低出生体重(VLBW,1000g≤BW<1500g)组(n=387)、低出生体重组(LBW,1500g≤BW<2500g)组(n=1873)、正常出生体重(NBW,2500g≤BW≤4000g)组(n=1072)。于生后72h^7d内采血进行FC浓度测定并进行比较。结果 EPTB、VPTB组FC浓度明显高于MPTB、LPTB组(P<0.05),MPTB组FC浓度明显高于LPTB组(P<0.05);胎龄越小,FC的95%医学参考范围下限越高。ELBW、VLBW组FC浓度明显高于LBW、NBW组(P<0.05),LBW组FC浓度明显高于NBW组(P<0.05);出生体重越低,FC的95%医学参考范围下限越高。结论 极/超早产儿、极/超低出生体重儿血FC浓度明显升高,并且随着胎龄及出生体重的增加呈明显下降的趋势。
Objective To examine blood concentrations of free carnitine (FC) in preterm infants with different gestational ages (GA) and birth weights (BW). Methods A total of 3 368 preterm infants were enrolled as subjects. According to GA, they were divided into extremely preterm birth (EPTB) group (GA <28 weeks;n=39), very preterm birth (VPTB) group (28 ≤GA <32 weeks;n=405), moderately preterm birth (MPTB) group (32 ≤GA <34 weeks;n=507), and late preterm birth (LPTB) group (34 ≤GA <37 weeks;n=2 417);according to BW, they were divided into extremely low birth weight (ELBW) group (BW <1 000 g;n=36), very low birth weight (VLBW) group (1 000 g ≤BW <1 500 g;n=387), low birth weight (LBW) group (1 500 g ≤BW <2 500 g;n=1 873), and normal birth weight (NBW) group (2 500 g ≤BW <4 000 g;n=1 072). Blood concentrations of FC were measured between 72 hours and 7 days after birth. Results The EPTB and VPTB groups had significantly higher FC concentrations than the MPTB and LPTB groups (P<0.05), and the MPTB group had significantly higher FC concentrations than the LPTB group (P<0.05). The lower limit of the 95% medical reference range of FC increased with the reduction in GA. The ELBW and VLBW groups had significantly higher FC concentrations than the LBW and NBW groups (P<0.05). The LBW group had significantly higher FC concentrations than the NBW group (P<0.05). The lower limit of the 95% medical reference range of FC increased with the reduction in BW. Conclusions There is a significant increase in blood FC concentrations in very/extremely preterm infants and very/ extremely low birth weight infants, and tend to decrease with the increases in GA and BW.
作者
齐志业
段江
王琼
姚勤
钟庆华
张彩营
梁琨
QI Zhi-Ye;DUAN Jiang;WANG Qiong;YAO Qin;ZHONG Qing-Hua;ZHANG Cai-Ying;LIANG Kun(Department of Pediatrics, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China)
出处
《中国当代儿科杂志》
CAS
CSCD
北大核心
2019年第6期562-566,共5页
Chinese Journal of Contemporary Pediatrics
基金
云南省高层次卫生技术人才培养(学科带头人)基金资助项目(D-201609)
关键词
游离肉碱
胎龄
出生体重
医学参考范围
早产儿
Free carnitine
Gestational age
Birth weight
Medical reference range
Preterm infant
