摘要
目的:观察益气活血化痰汤治疗慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)伴呼吸衰竭的临床疗效。方法:将80例COPD伴呼吸衰竭患者按照随机数字表法分为对照组和观察组,每组各40例。对照组给予常规西医治疗,观察组在对照组的基础上加用益气活血化痰汤。比较两组患者治疗前后中医证候积分、肺功能指标[用力肺活量(forced vital capacity,FVC)、第1秒用力呼气容积(Forced expiratory volume in one second,FEV1)、FEV1/FVC]、血气分析指标[动脉血氧分压(PaO2)、动脉二氧化碳分压(PaCO2)]、日排痰量、呼吸困难程度、免疫指标(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)变化情况。结果:观察组有效率为92.50%,对照组有效率为75.00%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后中医证候积分、日排痰量、mMRC评分均显著低于同组治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。两组患者治疗后FVC、FEV1、FEV1/FVC、PaO2、CD3^+、CD4^+、CD4^+/CD8^+检测结果高于同组治疗前,PaCO2、CD8^+低于同组治疗前,观察组治疗后FVC、FEV1、FEV1/FVC、PaO2、CD3^+、CD4^+、CD4^+/CD8^+高于对照组,PaCO2、CD8^+低于对照组,差异有统计学意义(P<0.05)。结论:益气活血化痰法治疗慢性阻塞性肺疾病伴呼吸衰竭可明显改善患者的肺功能和免疫功能。
Objective: To observe the clinical curative effect of Decoction for Boosting Qi and Promoting Blood Circulation and Resolving Phlegm on chronic obstructive pulmonary disease combined with respiratory failure. Methods: Eighty patients with COPD combined with respiratory failure were divided into the control group and the observation group according to the random number table method,with 40 cases in each group. The ones in the control group were treated with conventional Western medicine,and the ones in the observation group were supplemented with Decoction for Boosting Qi and Promoting Blood Circulation and Resolving Phlegm on the basis of the control group. Then the changes of TCM syndrome scores,lung function indexes including forced vital capacity ( FVC),forced expiratory volume in one second ( FEV1),FEV1 /FVC,blood-qi analysis indexes,including arterial oxygen partial pressure ( PaO2),and arterial carbon dioxide partial pressure ( PaCO2),daily sputum volume,dyspnea degree, and immune indicators ( CD3^+,CD4^+,CD8^+,CD4^+/CD8^+) before and after the treatment were compared in the two groups. Results: The effective rate of the observation group was 92. 50%,and that of the control group was 75. 00%. The difference between the two groups was statistically significant ( P < 0. 05). The TCM syndrome scores,daily sputum volume and mMRC scores of the two groups were significantly lower than those of the same group before the treatment,and the observation group was lower than the control group,and all the differences were statistically significant (P<0.05). After the treatment,the detection results of FVC,FEV1,FEV1 /FVC,PaO2,CD3^+,CD4^+,CD4^+/CD8^+ in the two groups were higher than those in the same group before the treatment;PaCO2 and CD8^+ were lower than those in the same group before the treatment;FVC, FEV1,FEV1 /FVC,PaO2,CD3^+,CD4^+,CD4^+/CD8^+ in the observation group were higher than those in the control group,but its PaCO2 and CD8^+ were lower than those in the control group,and all the differences were statist
作者
焦小强
周继红
李晶
姚楷南
李竺宜
李珏卉
JIAO Xiao-qiang;ZHOU Ji-hong;LI Jing;YAO Kai-nan;LI Zhu-yi;LI Jue-hui(Shenzhen Baoan District Hospital of TCM,Shenzhen,Guangdong,China,518133)
出处
《河南中医》
2019年第6期890-893,共4页
Henan Traditional Chinese Medicine
基金
2014年度深圳市宝安区科技创新课题项目(2014099)
关键词
慢性阻塞性肺疾病
呼吸衰竭
益气活血化痰法
chronic obstructive pulmonary disease ( COPD)
respiratory failure
Decoction for Boosting Qi and Promoting Blood Circulation and Resolving Phlegm
