摘要
目的:探讨多囊卵巢综合征(PCOS)患者的临床特征、中医证素及证候分布规律、不同证型PCOS患者相关指标的观察及其与年龄、月经稀发、不孕症及肥胖的相关性。方法:制定信息采集表,采用横断面调查的方法,收集分别来自5所医院的518例PCOS患者临床资料,进行数据分析。结果:518例PCOS者中,临床特征以月经稀发(72.39%)、不孕(20.08%)为主;病位类证候要素出现主要为肾(64.00%)、肝(61.20%)和脾(37.64%);病性类证素出现主要为血瘀(50.39%)、气虚(39.77%)、气滞(22.01%);常见证候类型为肾虚血瘀(34.75%)、肾气不足(25.10%)、肝郁脾虚(24.90%)、脾气虚弱(20.80%);肾虚血瘀证与不孕症呈正相关(P<0.05),肾气不足证与年龄呈正相关(P<0.05)。结论:PCOS患者的病位主要在肾,月经稀发为最常见的临床特征,血瘀为最常见的证素,最常见的证候类型是肾虚血瘀,该类患者更易出现不孕症;随着年龄的增长,PCOS患者的证型趋向于以肾气不足为主。临床上应辨证施治,结合患者不同证素及证候类型,予以针对性的治疗。
Objective:To investigate the clinical characteristics of the patients with polycystic ovary syndrome(PCOS),TCM syndromes elements and the distribution of the syndromes,and to explore the correlations of the related indexes of different syndromes of PCOS to age,sparse period,infertility and obesity.Methods:The data of 518 patients with PCOS from 5 hospitals were collected and analyzed by cross-sectional survey.Results:Among 518 patients with PCOS,the main clinical features were sparse period(72.39%)and infertility(20.08%).The main syndrome elements were Kidney(64.00%),Liver(61.20%)and Spleen(37.64%).The main syndromes were blood stasis(50.39%),qi deficiency(39.77%)and qi stagnation(22.01%).The common syndrome patterns were Kidney deficiency and blood stasis(34.75%),Kidney-qi deficiency(25.10%),Liver depression and spleen deficiency(24.90%)and Spleen-qi deficiency(20.80%).The syndrome of Kidney deficiency and blood stasis was positively correlated with infertility(P<0.05),and the syndrome of Kidney-qi deficiency was positively correlated with age(P<0.05).Conclusion:The disease location of PCOS is mainly in Kidney,the most common clinical feature is sparse period,blood stasis is the most common syndrome element,the most common syndrome pattern is Kidney deficiency and blood stasis,with which the patients are more prone to infertility.With the increase of age,the syndrome pattern of PCOS tends to be Kidney-qi deficiency.Clinical treatment should be based on syndrome differentiation,and targeted treatment should be given according to different syndrome elements and syndrome patterns of the patients.
作者
征征
刘艳霞
鲁秋丹
仰艳
刘海涛
沈凌宇
徐彩
边玉培
肖双双
孙俊建
邢玉
ZHENG Zheng;LIU Yanxia;LU Qiudan;YANG Yan;LIU Haitao;SHEN Lingyu;XU Cai;BIAN Yupei;XIAO Shuangshuang;SUN Junjian;XING Yu(Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital of Beijing University of Chinese Medicine,Beijing 100078,China;Beijing Xuanwu Hospital of Traditional Chinese Medicine,Beijing 100032,China;Beijing Shunyi Hospital of Traditional Chinese Medicine,Beijing 101300,China;Beijing Gulou Hospital of Traditional Chinese Medicine,Beijing 100010,China;Beijing First Hospital of Integrated Chinese and Western Medicine,Beijing 100020,China)
出处
《中医药学报》
CAS
2021年第11期68-72,共5页
Acta Chinese Medicine and Pharmacology
基金
国家自然科学基金(81904241)。
关键词
多囊卵巢综合征
证素
证候
相关性研究
肾虚血瘀
辨证论治
Polycystic ovary syndrome
Syndrome elements
Syndromes
Relevant researches
Kidney deficiency and blood stasis
Treatment based on syndrome differentiation
