摘要
胸腺基质淋巴细胞生成素(thymic stromal lymphopoietin,TSLP)是一种与白细胞介素(interleukin,IL)-7类似的炎性细胞因子。TSLP可作用于各种类型的免疫细胞及肿瘤细胞,参与多种过敏性疾病、慢性炎症、自身免疫性疾病及肿瘤的发生、发展。现就TSLP的一般生物学特性及TSLP与不同恶性肿瘤发生、发展关系的最新研究进行综述,旨在总结其参与恶性肿瘤发生、发展的作用机制并为临床诊断、治疗提供新思路。
Thymic stromal lymphopoietin(TSLP)is an inflammatory cytokine similar to interleukin(IL)-7.TSLP can act on various types of immune cells and tumor cells and participate in the development of various allergic diseases,chronic inflammation,autoimmune diseases and tumors.This review summarized the general biological characteristics of TSLP and the relationship between TSLP and different malignant tumors.Understanding the role of TSLP in the development of malignant tumors may provide new ideas for the diagnosis and treatment of TSLP-related diseases.
作者
申抒展
王佩茹
王秀丽
Shen Shuzhan;Wang Peiru;Wang Xiuli(Institute of Photomedicine,Shanghai Skin Disease Hospital,Tongji University School of Medicine,Shanghai 200443,China)
出处
《国际免疫学杂志》
CAS
2019年第3期306-310,共5页
International Journal of Immunology
基金
国家自然科学基金面上项目(81872212,81472538)
中央高校基本科研业务费专项资金资助(221201800101).
