摘要
目的 分析大剂量阿托伐他汀钙对急性缺血性脑卒中患者神经功能的保护作用。方法 将洛阳市第一人民医院90例急性缺血性脑卒中患者以随机数表法分为大剂量组和常规组各45例,均给予阿托伐他汀钙治疗,大剂量组初始剂量40mg/d,常规组为10mg/d,连续治疗24周。评估2组治疗前后神经功能、生活能力,比较2组治疗前后血脂、炎症因子水平及斑块面积变化,并评估2组用药安全性。结果 2组治疗前NIHSS评分、Barthel指数评分、血脂、炎症因子水平及斑块面积比较差异无统计学意义(P>0.05),治疗2周、24周大剂量组NIHSS评分均显著低于常规组(P<0.05),Barthel指数评分显著高于常规组(P<0.05);治疗后大剂量组TC、TG、CRP水平均明显低于常规组(P<0.05),斑块面积明显小于常规组(P<0.05);2组不良反应率比较差异无统计学意义(P>0.05)。结论 大剂量阿托伐他汀钙对急性缺血性脑卒中患者神经功能保护作用更显著,其作用机制可能与调节血脂、炎症因子水平及缩小斑块面积有关,对改善患者日常活动能力有重要意义。
Objective To investigate the protective effect of large dose ofatorvastatin calcium on neurological function of patients with acute ischemic stroke. Methods 90 cases with acute ischemic stroke were selected and divided into two groups,45 cases in each group.They were all given atorvastatin calcium,predose of large dosage group and common group were 40 mg/d and 10 mg/d,they were given 24 weeks of continuous treatment.Evaluate the neurological function,life ability,drug safety of the two groups before and after treatment.Compare the blood fat,levels of inflammatory cytokine,patch area changes of the two groups before and after treatment. Results Before treatment,Barthel score,blood fat,levels of inflammatory cytokine,patch area of the two groups had no statistic significance ( P >0.05),2 weeks,24 weeks after treatment,NIHSS score of large dose group was lower than common group ( P <0.05),Barthel score was higher than common group ( P <0.01);after treatment,TC,TG,CRP level of large dose group was lower than common group ( P <0.05),patch area was obviously less than control group ( P <0.05);adverse reaction rate of the two groups had no statistic significance ( P >0.05). Conclusion Large dose of atorvastatin calcium has significant effect on neurological function of patients with acute ischemic stroke,it can improve daily living activity of patients.
作者
刘玲
LIU Ling(Department of Neurology,the First People’s Hospital of Luoyang,Luoyang 471000,China)
出处
《中国实用神经疾病杂志》
2019年第10期1105-1110,共6页
Chinese Journal of Practical Nervous Diseases
