摘要
目的对213例淋巴结病变患者进行γ-干扰素释放酶联免疫试验(TB-IGRA),探讨其在淋巴结结核病诊断中的临床价值。方法收集2015年10月至2016年4月就诊的淋巴结病变患者213例,其中确诊为淋巴结结核132例,非结核病的对照组81例,均进行TB-IGRA试验,并与传统的血清腺苷脱氨酶(ADA)和结核抗体相比较,分析其对淋巴结结核病诊断的灵敏度和特异性。结果TB-IGRA的敏感度87.8%、特异性70.4%,结核抗体检测的灵敏度68.2%、特异性66.7%,血清ADA的灵敏度5.3%、特异性76.5%。结论TB-IGRA试验在淋巴结结核病的诊断中具有相对较高的敏感度,可用于临床上淋巴结结核病的筛查。
Objective To evaluate the clinical value of gamma interferon releasing enzyme linked immunosorbent assay(TB-IGRA)in the diagnosis of lymph node tuberculosis in a cohort of 213 patients with lymph node disease. Methods 213 cases of lesions were collected from October,2015 to April,2016.Among them,132 patients were diagnosed with lymph node tuberculosis,while the control group had 81 cases of non-tuberculosis.Both groups were examined by TB-IGRA test,and the results were compared with the serum adenosine deaminase(ADA)and traditional tuberculosis antibody.The sensitivity and specificity of the diagnosis of lymph node tuberculosis were then evaluated. Results The sensitivity of TB-IGRA was 87.8%,and the specificity was 70.4%.The sensitivity of tuberculosis antibody detection was 68.2%,and the specificity was 66.7%.The sensitivity of serum ADA was 5.3%,and the specificity was 76.5%. Conclusion TB-IGRA test has a relatively high sensitivity in the diagnosis of lymph node tuberculosis,and can be used for the clinical screening of lymph node tuberculosis.
作者
夏厦
张国英
郭一迪
吕连峥
窦慧
XIA Xia;ZHANG Guo-ying;GUO Yi-di;LYU Lian-zheng;DOU Hui(Department of Clinical Laboratory,Nanjing Integrated Traditional Chinese and Western Medicine Hospital,Nanjing 210014,China)
出处
《标记免疫分析与临床》
CAS
2019年第6期954-956,959,共4页
Labeled Immunoassays and Clinical Medicine
