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重组促黄体生成素在卵巢储备正常不孕症中的应用及提高优质胚胎率的价值分析 被引量:2

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摘要 目的探究卵巢储备正常不孕症中应用重组促黄体生成素(r-LH)对于提高优质胚胎率的价值。方法 200例行体外受精/胞浆内单精子注射-胚胎移植术(IVF/ICSI-ET)治疗的卵巢储备正常不孕症患者作为研究对象,随机分为对照组和观察组,每组100例。经短效促性腺激素释放激素激动剂(GnRH-a)长方案至卵泡发育后期,对照组单纯予以重组人卵泡刺激素注射液(商品名:果纳芬, r-FSH)进行治疗,观察组在对照组基础上加用r-LH进行治疗。观察比较两组患者的血清指标、实验室指标以及临床指标情况。结果在实施人绒毛膜促性腺激素(hCG)日时,观察组患者的血清黄体生成素(LH)、雌二醇(E2)及血清E2/≥14 mm卵泡数分别为(1.51±0.37)mIU/ml、(2278.30±107.30)pg/ml、(261.27±33.70),均明显高于对照组的(0.98±0.43)mIU/ml、(1742.50±98.40)pg/ml、(153.52±37.90),差异均有统计学意义(P<0.05)。观察组患者的获卵数、成熟卵子数、优质胚胎数、妊娠率及种植率分别为(14.3±3.7)个、(11.8±3.6)个、(7.4±2.7)个、68.0%、59.0%,均明显高于对照组的(9.8±2.4)个、(8.4±2.3)个、(3.5±0.9)个、40.0%、21.0%,差异均有统计学意义(P<0.05)。结论卵巢储备正常不孕症患者的超促排卵方案实施过程中应用r-LH治疗可有效促进排卵与胚胎发育,提高优质胚胎率。
出处 《中国实用医药》 2019年第15期100-101,共2页 China Practical Medicine
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