摘要
目的研究分析重组促黄体生成素在卵巢储备正常患者超促排卵中的作用。方法随机选择进行体外受精/胞浆内单精子注射-胚胎移植术的不孕症患者180例为研究对象,在短效GnRH激动剂长方案中的卵泡发育后期将其平均分为A、B、C组,A组患者加用重组促黄体生成素治疗,B组加用尿促性素治疗,C组继续单用r-FSH(果纳芬,重组人卵泡刺激素注射液)治疗,针对3组患者的血清各项指标、实验室检查各项指标进行对比分析。结果在实施绒毛膜促性腺激素日时C组患者的血清LH、E_2值明显低于A组和B组患者,差异有统计学意义(P<0.05);且A组与B组患者的血清LH、E_2值差异有统计学意义(P<0.05)。实施绒毛膜促性腺激素日时血清E_2/≥14 mm卵泡数A组明显高于B、C组,差异有统计学意义(P<0.05)。获卵数、成熟卵子数、优质胚胎数、临床妊娠率A组高于C组,B组高于C组,且差异有统计学意义(P<0.05)。A组的优质胚胎数、临床妊娠率、种植率高于B组,差异有统计学意义(P<0.05)。结论重组促黄体生成素在卵巢储备正常不孕症患者的治疗中可以促进提高优质胚胎率、临床妊娠率,有良好的临床应用效果。
Objective To study and analyze the role of recombinant luteinizing hormone in ovarian hyperstimulation for patients with normal ovarian reserve. Methods From November 2013 to December 2014,180 infertile patients were randomly selected,who were administrated by in vitro fertilization / intracytoplasmic single sperm injection-embryo transplantation. In late stage of follicular development within short-acting GnRH agonist long program,the patients were divided into Group A,B,C. In Group A,patients were treated additionally with recombinant luteinizing hormone,and Group B with additional urine gonadotrophin,and Group C with r-FSH（ fruit Finn,recombinant human follicle stimulation hormone injection） continually. Patients＇ serum indicators and laboratory examination indexes of the three groups were analyzed. Results On the day of implement of human chorionic gonadotropin,patients in Group C had obviously lower serum LH,serum E_2 than those in Group A and Group B,and the difference had statistical significance（ P〈0. 05）,and serum LH,serum E_2 values had significant difference between Group A and Group B（ P〈0. 05）. On the day of implement of human chorionic gonadotropin,serum E_2/ ≥14 mm follicle number was significantly higher than those in Group B and Group C with significant difference（ P〈0. 05）. Numbers of retrieved oocytes,mature eggs,high quality embryos,and clinical pregnancy rate in Group A were higher than those in Group C,and Group B were higher than those in Group C with significant difference（ P〈0. 05）. In Group A,numbers of high quality embryos,clinical pregnancy rate,planting rate were higher than those in Group B,and the difference had statistical significance（ P〈0. 05）. Conclusion In treatment for infertile patients with normal ovarian reserve,recombinant luteinizing hormone can increase high quality embryos rate,clinical pregnancy rate,which has a good clinical application effects.
出处
《中国妇幼保健》
CAS
2016年第2期336-338,共3页
Maternal and Child Health Care of China
基金
无锡市医院管理中心医学技术联合攻关项目(YGZX1204)
关键词
重组促黄体生成素
体外受精/胞浆内单精子注射-胚胎移植术
控制性超排卵
Recombinant luteinizing hormone
In vitro fertilization / intracytoplasmic single sperm injection-embryo transplantation
Controlled superovulation
