摘要
自身抗体升高是自身免疫性甲状腺疾病(AITD)的主要特点,这种变化有赖于CD4^+T细胞与B细胞相互作用.滤泡辅助性T细胞(Tfh)是一类新的CD4^+T细胞亚群,主要功能是促进生发中心形成,辅助B细胞分泌高亲和力抗体、促进抗体类别转换,滤泡调节性T细胞(Tfr)与Tfh有共同表征,以各种方式抑制Tfh细胞和(或)B细胞来特异性调节生发中心反应,抑制抗体产生.研究发现,AITD患者外周血Tfr/Tfh比例失衡,外周血及甲状腺组织内Tfh比例显著增加,并与甲状腺激素和甲状腺自身抗体等水平呈正相关,经治疗后Tfh比例降低.深入研究Tfh、Tfr,调节自身抗体水平可能成为AITD治疗的新方向.
Elevated autoantibodies, which are generated by the interaction of CD4^+ T cells with B cells, are main features of autoimmune thyroid disease(AITD). Follicular helper T cells (Tfh ) are a new class of CD4^+ T cell that specialize in stimulating germinal centre (GC) formation, helping naive B cells to secrete high-affinity antibodies, to promote antibody class switching in GC. Follicular regulatory T cells (Tfr) share the same molecules with Tfh. Tfr can specifically suppress Tfh and B cells to control the GC reaction so as to restrain the production of autoantibody. Studies showed there existed imbalance of Tfh/Tfr and increased percentages of circulating Tfh, a positive correlation between the percentages of circulating Tfh and serum concentrations of thyroid hormone and thyroid autoantibodies in patients with AITD, and decreased percentage of circulating Tfh after treatment. Further study of Tfh and Tfr, especially the regulation of autoantibodies may become a new direction for the treatment of AITD.
作者
相萍萍
刘超
Xiang Pingping;Liu Chao(Endocrine and Diabetes Center,Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine,Jiangsu Province Academy of Traditional Chinese Medicine,Nanjing 210028,China)
出处
《国际内分泌代谢杂志》
2019年第3期168-172,共5页
International Journal of Endocrinology and Metabolism
基金
国家自然科学基金(81471010)
国家中医药管理局重大疑难疾病中西医临床协作试点项目(2018)
江苏省中医药领军人才(SLJ0209).
