摘要
目的 了解目前烟台地区成人及青少年肺炎支原体肺炎(MPP)的发病特点及肺炎支原体(MP)对常用抗生素的敏感性,以期指导本地区MPP的经验治疗。方法 选择2016年9月-2018年3月就诊于我院且符合条件的社区获得性肺炎(CAP)病人,收集其急性期咽拭子标本,通过细菌培养及聚合酶链反应(PCR)检测MP确定MPP。分析MPP病人的发病特点。采用微量稀释法测定大环内酯类、喹诺酮类及四环素类抗生素对MP的最小抑菌浓度(MIC),评价药物敏感性。结果 177例CAP病人中,共检出MPP病人40例,占22.6%。MPP病人的发病年龄低于非MPP病人(t=27.97,P<0.01),且体温更高(t=2.97,P<0.01),两组病人其他临床特征差异无显著性(P>0.05)。共分离培养到MP菌株20株,对大环内酯类抗生素全部耐药。结论 MP倾向于感染年轻人,但MPP临床特征无典型性,给诊断增加了难度。烟台地区成人及青少年MPP病人的耐药形势相当严峻。
Objective To investigate the clinical features of adults and adolescents with Mycoplasma pneumoniae pneumonia (MPP) and their sensitivity to commonly used antibiotics in Yantai, China, and to provide guidance to empirical therapy for MPP in this area. Methods The patients with community-acquired pneumonia (CAP) who visited our hospital from September 2016 to March 2018 and met the inclusion criteria were enrolled. Throat swabs were collected during the acute stage, and bacterial culture and polymerase chain reaction were used for the detection of Mycoplasma pneumoniae (MP) to make a confirmed diagnosis of MPP. The clinical features of MPP patients were analyzed. The microdilution method was used to determine the minimal inhibitory concentrations of macrolides, quinolones, and tetracyclines against MP, and the sensitivities of the drugs were evaluated. Results Of all 177 patients with CAP, 40(22.6%) were diagnosed with MPP. Compared with those without MPP, the patients with MPP had a significantly younger age of onset (t =27.97, P <0.01) and a significantly higher body temperature (t =2.97, P <0.01), while there were no significant differences in other clinical features between the two groups (P >0.05). A total of 20 strains of MP were obtained, and all of them were resistant to macrolides. Conclusion MP tends to infect young patients, but MPP lacks typical clinical features, which increases the difficulty in the diagnosis of MPP. The situation of drug resistance is still severe in adult and adolescent MPP patients in Yantai.
作者
王姣
于红霞
蒲增惠
WANG Jiao;YU Hongxia;PU Zenghui(Department of Infection, Yantai Yuhuangding Hospital, Qingdao University, Yantai 264000, China)
出处
《青岛大学学报（医学版）》
CAS
2019年第3期317-320,324,共5页
Journal of Qingdao University(Medical Sciences)
基金
山东省医药卫生科技发展计划项目(2017WS165)
关键词
肺炎支原体
肺炎
支原体
疾病特征
抗药性
Mycoplasma pneumoniae
pneumonia,Mycoplasma
disease attributes
drug resistance
