摘要
腹腔镜手术具有创伤性小、患者术后恢复快、遗留的疤痕小等优点,在诊断与治疗疾病中的应用十分广泛。但是,使用腹腔镜手术治疗肿瘤的安全性仍存在争议,其中主要的争议是对肿瘤患者实施手术时建立CO_2气腹是否会促进其盆腹肿瘤细胞的增殖、侵袭与迁移。有研究人员认为,对卵巢癌患者实施手术时以CO_2作为介质为其建立气腹可导致腹膜结构破坏、代谢紊乱和免疫功能下降等情况,增强肿瘤细胞的增殖、侵袭与迁移的能力,并可诱发穿刺孔转移瘤。也有学者认为,腹腔镜手术后肿瘤细胞的种植转移与对患者实施手术的类型及建立CO_2气腹无关,主要是因手术过程中施术者操作不当所致。本文主要介绍近年来关于CO_2对卵巢肿瘤增殖侵袭能力影响的研究进展。
laparoscopic surgery is widely used in the diagnosis and treatment of diseases due to its advantages of less trauma,faster postoperative recovery and less scar.However,the safety of laparoscopic surgery in the treatment of tumors is still controversial,among which the main controversy is whether the establishment of CO2 pneumoperitoneum in the operation of tumor patients will promote the proliferation,invasion and migration of pelvic tumor cells.Some researchers believe that the establishment of pneumoperitoneum with CO2 as the medium in the operation of ovarian cancer patients can lead to peritoneal structure destruction,metabolic disorders and decreased immune function,enhance the ability of tumor cell proliferation,invasion and migration,and induce puncture hole metastasis.Some scholars also believe that the implantation and metastasis of tumor cells after laparoscopic surgery are unrelated to the type of surgery performed on patients and the establishment of CO2 pneumoperitoneum,which is mainly caused by improper operation of the operator during the operation.This article mainly introduces the research progress of the effect of CO2 on the proliferation and invasion ability of ovarian tumor in recent years.
作者
周建鸿
张颖
Zhou jianhong;zhang ying(guangdong medical university,zhanjiang 524000)
基金
广东省自然科学基金项目编号:2017A030313559
关键词
腹腔镜手术
CO2
卵巢癌
增殖
侵袭
腹膜
laparoscopic surgery
CO2
Ovarian cancer
Proliferation
Attacks
peritoneal
