摘要
目的探讨新辅助化疗(NACT)联合全结肠系膜切除术(CME)治疗结直肠癌的临床效果。方法回顾性分析2015年2月至2018年2月医院收治的72例结直肠癌患者的临床资料,将行NACT联合CME治疗的41例患者设为联合组,实施单纯CME治疗的31例患者设为对照组。比较两组患者的治疗效果。结果治疗后,两组患者血清CA724、TuM2-PK及TSGF水平均显著降低,且联合组均明显低于对照组(P<0.05)。治疗后,联合组的临床分期明显优于对照组(P<0.05)。联合组的局部复发率及并发症总发生率均明显低于对照组(P<0.05)。结论NACT联合CME治疗结直肠癌患者效果显著,可显著改善患者肿瘤相关指标,提高治疗效果,降低局部复发率及并发症总发生率。
Objective To investigate the clinical effect of neoadjuvant chemotherapy (NACT) combined with complete mesocolic excision (CME) in the treatment of colorectal cancer.Methods The clinical data of 72 patients with colorectal cancer admitted in our hospital from February 2015 to February 2018 were retrospectively analyzed.A total of 41 patients treated with NACT combined with CME were assigned to combined group and 31 patients treated with CME alone were assigned to control group.The therapeutic effects of the two groups were compared.Results After treatment, the levels of serum CA724, TuM2-PK and TSGF significantly decreased in both groups, and those in the combined group were significantly lower than the control group (P<0.05).After treatment, the clinical stage of the combined group was significantly better than that of the control group (P<0.05).The local recurrence rate and the total incidence of complications in the combined group were significantly lower than those in the control group (P<0.05).Conclusion NACT combined with CME is effective in the treatment of colorectal cancer.It can significantly improve the levels of tumor-related indicators and the treatment effect, reduce the local recurrence rate and the incidence of complications.
作者
赵健
张云锋
ZHAO Jian;ZHANG Yun-feng(Qishan County Hospital,Baoji 722400;the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China)
出处
《临床医学研究与实践》
2019年第15期56-58,共3页
Clinical Research and Practice
关键词
新辅助化疗
全结肠系膜切除术
结直肠癌
neoadjuvant chemotherapy
complete mesorectal excision
colorectal cancer
