摘要
癫痫是中枢神经系统的兴奋与抑制失衡导致短暂性大脑功能障碍的一种慢性脑部疾病。肠道菌群能够通过脑肠轴影响大脑的功能信号,同时脑信号也能够影响微生物活动和胃肠道生理。本文现围绕癫痫患者肠道微生物的变化和肠道微生物对癫痫的可能影响机制综述如下。
Epilepsy is a chronic disease of transient brain dysfunction caused by imbalance between excitation and inhibition of central nervous system.Gut microbiota can affect the functional signals of the brain through brain-gut-microbiota axis.At the same time,brain signals can also affect microbial activities and gastrointestinal physiology.This article reviews the recent research progress on changes of intestinal microorganisms in epilepsy patients and possible mechanism of intestinal microorganisms affecting epilepsy.
作者
陈婷
陈娅
张海清
徐祖才
Chen Ting;Chen Ya;Zhang Haiqing;Xu Zucai(Graduate School,Zunyi Medical University,Zunyi 563100,China;Department of Neurology,Affiliated Hospital of Zunyi Medical College,Zunyi 563100,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2019年第4期413-416,共4页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81660227、81560224).
关键词
肠道微生态
脑肠轴
癫痫
免疫
神经递质
Gut microbiota
Brain-gut-microbiota axis
Epilepsy
Immune
Neurotransmitter
