摘要
结直肠癌是最常见的恶性肿瘤之一,在全球恶性肿瘤中发病率排第三位及死亡率排第二位。而继发性耐药及转移复发成为结直肠癌药物治疗的重要挑战。越来越多的证据表明,长链非编码RNA (long non-coding RNA, lncRNA)可以通过表观遗传机制调节肿瘤中相关基因的表达从而在肿瘤发生发展及转移中发作重要作用。尿路上皮癌相关基因1 (urothelial cancer associated 1, UCA1)在包括结直肠癌的多种肿瘤中均发现有高表达,并且可以通过与染色质修饰体相互作用、直接调节染色体成环及成为微小RNA(microRNA, miRNA)海绵(sponge)等机制在表观遗传学水平上调节转录表达。该文将对UCA1在结直肠癌中作用及其调节机制的研究进展作一概述。
Colorectal cancer is one of the most common malignant tumors.It ranks third in the global malignant tumor and ranks second in mortality.Secondary drug resistance and metastasis and recurrence have become important challenges in the treatment of colorectal cancer.There is increasing evidence that long non-coding RNAs(lncRNAs)can regulate the expression of related genes in tumors through epigenetic mechanisms and play an important role in tumor development and metastasis.Urothelial carcinoma associated gene 1(UCA1)is highly expressed in a variety of tumors including colorectal cancer,and can directly regulate chromosomes into loops and become tiny by interacting with chromatin modifications.Mechanisms such as RNA(microRNA,miRNA)sponge regulate transcriptional expression at the epigenetic level.This article will provide an overview of the research progress in the role of UCA1 in colorectal cancer and its regulatory mechanisms.
作者
余伟
沈薇
YU Wei;SHEN Wei(Department of Gastroenterology,the Second Affiliated Hospital of Chongqing Medical University,Chongqing,400010 China)
出处
《系统医学》
2019年第6期192-195,198,共5页
Systems Medicine
关键词
长链非编码RNA
尿路上皮癌抗原1
结直肠癌
Long-chain non-coding RNA
Urothelial carcinoma antigen 1
Colorectal cancer
