摘要
Micro RNA(mi RNA)是一类小的非编码RNA,其通过在转录后水平调控基因表达来调节多种生理和病理功能。越来越多的证据表明,micro RNA在大肠癌的发生发展中起着重要作用。MDM4是p53的主要调节因子,负调控p53转录活性,在多种肿瘤发病中是极为重要的因素之一。为了更好地理解大肠癌涉及的分子途径,为大肠癌患者的诊疗和改善预后提供更多的选择,现对micro RNA表观遗传学与MDM4基因对大肠癌细胞调控的研究现状作一综述。
MicroRNAs(miRNAs)are a class of small noncoding RNAs that regulate a variety of physiological and pathological functions by modulating gene expression at the posttranscriptional level.Accumulating evidence indicates that microRNAs play an important role in the development of colorectal cancer.MDM4 is a master regulator of p53 and negatively regulates p53 transcriptional activity.MDM4 is one of the most vital factors in the pathogenesis of various tumors.In this study,in order to understand the molecular pathways involved in colorectal cancer and provide more options for the diagnosis and treatment and improvement of prognosis of colorectal cancer patients,we focus on the current research status of microRNA epigenetics and MDM4 gene on the regulation of colorectal cancer cells.
作者
裴阳
马志斌
PEI Yang;MA Zhi-bin(The First Affiliated Hospital of Harbin Medicial University,Harbin,Heilongjiang 150001,China)
出处
《热带医学杂志》
CAS
2020年第10期1394-1398,共5页
Journal of Tropical Medicine
基金
黑龙江省自然科学基金(面上项目)(H2016039)。
