摘要
弥散张量成像(diffusion tensor imaging,DTI)作为一种观察大脑白质完整性和走行方向的无创性磁共振技术,为探索强迫症(obsessive compulsive disorder,OCD)的发病机制提供新的思路。目前强迫症的病因研究提示,除了经典的皮质纹状体丘脑皮质环路(cortical-striatum-thalamus-cortical,CSTC)以外,大脑顶叶、颞叶、枕叶等区域也参与了强迫症的发生;而白质纤维是大脑各脑区之间物质沟通的重要结构并受个体发育的影响,因此运用弥散张量成像技术探索强迫症患者大脑白质纤维的特点,明确在强迫症发生中的作用至关重要。本文就成人强迫症DTI研究中涉及钩束、上纵束、胼胝体的研究及儿童青少年强迫症DTI研究进展做一综述。
Diffusion tensor imaging (DTI), a noninvasive MRI technique for measuring the integrity and direction of white matter in the brain, is a promising method to explore the pathogenesis of obsessive compulsive disorder (OCD). At present, the etiological research of OCD suggests that, in addition to the classical cortical-striatum-thalamus-cortical (CSTC)circuit, the parietal lobe, temporal lobe, occipital lobe and other regions of the brain are also involved in the pathogenesis of OCD. White matter fibers are important structure of material information communication in various brain regions and affected by individual neurodevelopment. Therefore, it is very important to explore the characteristics of white matter fiber in the brain of patients with OCD by using diffusion tensor imaging technology clarifying its role in the occurrence of OCD. This paper reviews the studies on uncinate fasciculus, superior longitudinal fasciculus, corpus callosum in adult DTI studies and the progress of DTI studies on children and adolescents.
作者
顾秋梦
王振
Gu Qiumeng;Wang Zhen(Clinical Psychology Department,Shanghai Mental Health Center,Shanghai Jiaotong University School of Medicine,Shanghai 200030,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2019年第4期375-379,共5页
Chinese Journal of Behavioral Medicine and Brain Science
基金
国家自然科学基金项目(81671340)
上海市市级医疗卫生优秀学科带头人培养计划(2017BR058).
关键词
强迫症
弥散张量成像
纤维追踪
Obsessive-compulsive disorder
Diffusion tensor imaging
Diffusion tractography
