摘要
目的探究双相情感障碍(BPD)患者血清甲状腺素、泌乳素、多巴胺水平变化及与冲动攻击行为的相关性。方法选取2019年10月—2021年3月收治的85例BPD作为研究组,另选同期85例健康志愿者作为对照组,比较两组血清甲状腺素、泌乳素、多巴胺水平;分析BPD患者血清甲状腺素、泌乳素、多巴胺水平与外显攻击行为量表(MOAS)、Barratt冲动性量表第十一版(BIS-11)评分的相关性。比较疗效良好、疗效不良BPD患者治疗前后血清甲状腺素、泌乳素、多巴胺水平及各指标差值,分析各指标差值评价疗效的价值。结果研究组血清甲状腺素、泌乳素、多巴胺水平均高于对照组(P<0.05)。有冲动攻击行为BPD患者血清甲状腺素、泌乳素、多巴胺水平及MOAS、BIS-11评分均高于无冲动攻击行为患者(P<0.05);血清甲状腺素、泌乳素、多巴胺水平与MOAS和BIS-11评分分别呈正相关(P<0.01)。疗效良好BPD患者治疗前后血清甲状腺素、泌乳素、多巴胺水平均低于疗效不良患者,各指标差值均大于疗效不良患者(P<0.05)。血清甲状腺素、泌乳素、多巴胺差值评价BPD患者疗效的曲线下面积分别为0.843、0.901、0.760。结论BPD患者血清甲状腺素、泌乳素、多巴胺水平明显升高,且与冲动攻击行为呈正相关。各指标差值在评价BPD疗效方面具有一定价值。
Objective To explore the changes of serum thyroxine,prolactin and dopamine levels in patients with bipolar disorder(BPD)and their correlations with impulsive aggressive behavior.Methods A total of 85 patients with BPD who were admitted from October 2019 to March 2021 were selected as the research group,and 85 healthy volunteers at the same period were selected as the control group.The levels of serum thyroxine,prolactin and dopamine between the two groups were compared,and the correlation between serum thyroxine levels,prolactin,dopamine levels and the Modified Overt Aggression Scale(MOAS),Barratt impulsivity scale eleventh edition(BIS-11)score was analyzed.The serum thyroxine,prolactin,dopamine levels and the difference of each index were compared before and after treatment in BPD patients with good curative effect and poor curative effect,and the value of the difference of each index to evaluate the curative effect was analyzed.Results The levels of serum thyroxine,prolactin and dopamine in the research group were higher than those in the control group(P<0.05).Serum levels of thyroxine,prolactin,dopamine,MOAS,and BIS-11 scores in BPD patients with impulsive aggressive behavior were higher than those in patients without impulsive aggressive behavior(P<0.05).The levels of serum thyroxine,prolactin and dopamine were positively correlated with MOAS and and BIS-11 scores(P<0.01).The levels of serum thyroxine,prolactin and dopamine in BPD patients with good curative effect before and after treatment were lower than those in patients with poor curative effect,and the difference of each index before and after treatment was greater than that in patients with poor curative effect(P<0.05).The areas under the ROC curve of differences of serum thyroxine,prolactin,and dopamine in evaluating the efficacy of BPD were 0.843,0.901,and 0.760,respectively.Conclusion Serum levels of thyroxine,prolactin,and dopamine were significantly increased in BPD patients,and were positively correlated with impulsive aggressive behavior.The dif
作者
高海波
王刚
陈莎莎
李贺斌
马文有
GAO Hai-bo;WANG Gang;CHEN Sha-sha;LI He-bin;MA Wen-you(Department of Psychiatry,Kailuan Mental Health Centre,Tangshan,Hebei 063001,China;Department of Psychiatry,Kailuan General Hospital,Tangshan,Hebei 063000,China)
出处
《临床误诊误治》
CAS
2022年第5期112-116,共5页
Clinical Misdiagnosis & Mistherapy
基金
河北省卫生厅科研基金项目(20201279)。
