摘要
目的探讨维生素D受体(VDR)基因多态性与哮喘的关系。方法搜集检索国内外发表的VDR基因与哮喘相关性的文献。对纳入文献进行质量评价,提取有效数据,利用等位、显性、隐性基因模型做基因分型分析,计算合并比值比(OR)和95%置信区间(95%CI)。按人种、年龄和性别分层做亚组分析,同时进行异质性检验、敏感性分析以及发表性偏倚评估。结果共纳入16篇病例对照研究,其中病例组2 823例研究对象,对照组3 184例。结果显示Taq Ⅰ位点显性基因模型CC+CT比TT(OR=1.23,95%CI:1.05~1.44)、等位基因模型C比T(OR=1.23,95%CI:1.10~1.38)与哮喘患病有关,其余Apa Ⅰ、Bsm Ⅰ、Fok Ⅰ位点与哮喘患病无关。Taq Ⅰ位点亚组分析表明Taq Ⅰ位点基因变异在白种人或黑人、年龄>20岁和男性<50%各组均提示携带C基因可提高哮喘患病风险,而在黄种人、年龄≤20组和男性≥50%各组未表现出二者关联性。结论VDR基因Taq Ⅰ位点变异与哮喘患病有关,携带C基因可提高哮喘患病风险,但二者关联性存在人种、年龄和性别修饰效应。
Objective To explore the association of vitamin D receptor (VDR) gene polymorphisms with asthma. Methods The published studies both at home and abroad on the association between VDR genes and asthma were collected.Their qualities were evaluated and the related data of the included studies were extracted.The gene analyses were made by means of allele gene model, dominant gene model and recessive gene model, and the pooled odds ratios (OR) and their 95% confidence intervals (95%CI) were calculated.Sub-group analyses for race, age and sex, the heterogeneity analysis, the sensitivity analysis and the evaluation of publication bias were performed. Results A total of 2 823 cases and 3 184 controls from 16 case-control studies were included.The results of the study showed that there was a statistically significant association between Taq Ⅰ gene polymorphism and asthma in dominant model (CC+ CT vs TT, OR=1.23, 95%CI: 1.05-1.44) and allele model (C vs T, OR=1.23, 95%CI: 1.10-1.38). In contrast, no statistical significance was found between Apa Ⅰ, Bsm Ⅰ, Fok Ⅰ gene polymorphism and asthma.Subgroup analysis for Taq Ⅰ gene showed that in the White or Black race,>20 years and male <50% groups C gene carriers could increase the risk of asthma, however no statistically significant association was found in those subgroups of Yellow race,≤20 years, male≥50% group. Conclusions Taq Ⅰ gene polymorphism has the association with asthma and C gene carriers can increase the risk of asthma, but this effect is modified by race, age and sex.
作者
刘瑞芳
张蓉芳
李桂荣
雷苗
高文龙
Liu Ruifang;Zhang Rongfang;Li Guirong;Lei Miao;Gao Wenlong(Department of Epidemiology and Biostatistics,School of Public Health,Lanzhou University,Lanzhou 730000,China;Asthma Outpatient of International Medical Services,Gansu Provincial Hospital of Maternal and Child Health,Lanzhou 730050,China)
出处
《国际呼吸杂志》
2019年第7期487-494,共8页
International Journal of Respiration
基金
国家自然科学基金(81260001).
