摘要
目的:探讨丹参多酚酸盐与丹参酮治疗慢性心力衰竭患者的临床效果和机制。方法:将慢性心力衰竭患者136例作为研究对象,按照随机数字表法分为两组,每组各68例,在常规治疗的基础上研究组加用丹参酮Ⅱ_A进行治疗,对照组加用丹参多酚酸盐进行治疗,对比观察患者疗效。结果:研究组治疗后临床总有效率为95.59%,明显高于对照组73.53%(P<0.05);治疗后两组患者CRP和Hcy水平均发生明显降低,LVEF明显升高,研究组改善程度优于对照组(P<0.05);两组患者头痛、眩晕、血谷丙转氨酶水平升高等不良并发症发生率分别为5.88%和8.82%,组间比较差异无统计学意义(P>0.05),经过对症处理后消失。结论:使用丹参酮Ⅱ_A注射液治疗CHF的疗效优于使用丹参多酚酸盐。
Objective:To investigate the clinical effect and mechanism of tanshinone and salvianolate in the treatment of chronic heart failure.Methods:136 patients with chronic heart failure were divided into two groups according to random number table method,68 cases in each group.On the basis of routine treatment,the study group was treated with tanshinoneⅡA,and the control group was treated with tanshinone polyphenolic acid salt.The curative effect of the patients was compared and observed.Results:After treatment,the total effective rate of the study group was 95.59%,which was significantly higher than that of the control group(73.53%(P<0.05).After treatment,the levels of CRP and Hcy in the two groups decreased significantly,LVEF increased significantly,and the improvement degree of the study group was better than that of the control group(P<0.05).The incidence of adverse complications such as headache,vertigo and elevated serum glutamic-pyruvic transaminase in the two groups was 5.88%and 8.82%,respectively.The difference was not statistically significant(P>0.05),but disappeared after symptomatic treatment.Conclusion:TanshinoneⅡA injection is better than salvianolic acid salts in the treatment of CHF.The effect is remarkable.
作者
孙哲
杨默
石宗华
SUN Zhe;YANG Mo;SHI Zonghua(Department of General Medicine,the Fifth Affiliated Hospitalof Zhengzhou University(Zhengzhou 450052))
出处
《陕西中医》
2019年第5期591-593,共3页
Shaanxi Journal of Traditional Chinese Medicine
关键词
慢性心力衰竭
丹参酮
丹参多酚酸盐
疗效
机制
血谷丙转氨酶
Chronic heart failure
Tanshinone
Salvianolate
Effect
Mechanism
Serum glutamic-pyruvic transaminase
