摘要
目的观察丹参多酚酸盐联合常规西药治疗老年冠心病不稳定型心绞痛的临床疗效及对其血管内皮功能的影响,并分析其作用机制。方法将我院收治的80例老年冠心病不稳定型心绞痛患者随机分为观察组与对照组各40例,对照组予以常规西药治疗,观察组采取常规西药联合丹参多酚酸盐治疗,对比两组临床疗效及治疗前后血管内皮功能、微炎性反应状态。结果治疗后,观察组心绞痛与心电图治疗总有效率均明显高于对照组(P<0.05);观察组一氧化氮(NO)、血栓调节蛋白(TM)明显高于对照组(P<0.05)且内皮素(ET)明显低于对照组(P<0.05);观察组斑块厚度、斑块内增强强度、起效增强时间以及达峰时间均低于对照组(P<0.05);观察组超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)均低于对照组(P<0.05);两组治疗过程中均未发生严重不良反应。结论丹参多酚酸盐能够有效改善老年冠心病不稳定型心绞痛患者血管内皮功能及微炎性反应状态,强化不稳定型心绞痛症状的控制与疗效的提升,而其作用机制主要与丹参多酚酸盐的免疫病理学调节以及全面调控冠心病局部炎症反应与斑块的稳定性具有密切关系。
Objective To observe the clinical efficacy of Salvianolate Injection in treatment of unstable angina pectoris of coronary heart disease(CHD),and its effect on vascular endothelial function and micro inflammatory reaction state.Methods Eighty elderly patients with unstable angina pectoris of CHD were randomly divided into observation group and control group with 40 cases each.Control group was treated with conventional western medicine,and observation group was treated with Salvianolate Injection on the basis of control group.The effects of the two groups,as well as the vascular endothelial function and micro inflammatory reaction state before and after treatment were compared.Results After treatment,the total effective rates of angina pectoris and ECG in observation group were significantly higher than those in control group(P<0.05);nitric oxide(NO)and thrombomodulin(TM)in observation group were significantly higher than those in control group(P<0.05),and endothelin(ET)was significantly lower than those in control group(P<0.05);hypersensitivity C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)was lower in observation group than that of control group(P<0.05);there was no significant difference in the level of IL-6(P>0.05).Conclusion Salvianolate Injection combined with conventional western medicine can further improve its clinical treatment effect,strengthen the control of symptoms of unstable angina pectoris,and play a positive role in improving vascular endothelial function and micro inflammatory reaction state of patients in the treatment of unstable angina pectoris of CHD.
作者
吴乐
刘翠青
张轩
WU Le;LIU Cui-qing;ZHANG Xuan(Nantong Maternal and Child Health Hospital,Nantong 226000)
出处
《湖北中医药大学学报》
2023年第2期23-26,共4页
Journal of Hubei University of Chinese Medicine
基金
江苏省南通市市级科技计划(指导性)项目(项目编号:MSZ18083)。
关键词
老年冠心病不稳定型心绞痛
丹参多酚酸盐
血管内皮功能
微炎性反应状态
作用机制
Unstable angina pectoris of coronary heart disease
Salvianolate Injection
Vascular endothelial function
Microinflammatory reaction state
Mechanism of action
