摘要
目的探讨美托洛尔联合门冬氨酸钾镁盐治疗老年缺血性心律失常的临床疗效及对患者心功能的影响。方法回顾性分析2016年8月至2017年9月于安康市中心医院心内科接受治疗的98例老年缺血性心律失常患者的临床资料,根据不同的药物治疗方法将患者分为对照组和观察组各49例。对照组患者给予美托洛尔单纯治疗,观察组患者在对照组基础上加用门冬氨酸钾镁盐联合治疗,疗程为一个月。比较两组患者的临床治疗效果和动态心电图疗效,并对治疗前后的心功能指标和心律失常指标进行比较。结果观察组患者治疗后的临床治疗总有效率为95.92%,明显高于对照组的81.63%,动态心电图疗效总有效率为91.84%,明显高于对照组的83.67%,差异均有统计学意义(P<0.05);治疗后观察组患者的左室收缩末期内径为(44.78±6.42) mm,较对照组的(50.58±6.83) mm下降明显,心输出量和左室射血分数分别为(5.30±0.97) L/min、(41.29±8.56)%,较对照组的(4.60±0.89) L/min和(31.86±5.93)%上升明显,差异均有统计学意义(P<0.05);治疗后观察组患者的房性期前收缩、室性期前收缩和交界性期前收缩次数下降程度分别为(1 621±354)次/24 h、(1 291±109)次/24 h、(117±34)次/24 h,下降程度明显高于对照组的(3 200±457)次/24 h、(2 469±360)次/24 h、(262±46)次/24 h,差异均有统计学意义(P<0.05)。结论美托洛尔联合门冬氨酸钾镁盐治疗老年缺血性心律失常患者有利于改善患者的心功能,临床治疗效果显著,值得临床推广使用。
Objective To explore the efficacy of metoprolol combined with potassium magnesium aspartate in the treatment of ischemic arrhythmia in elderly patients and its effect on cardiac function.Methods The clinical data of 98 elderly patients with ischemic arrhythmia who received treatment in the Department of Cardiology,Ankang Central Hospital from August 2016 to September 2017 were retrospectively analyzed.The patients were divided into control group and observation group (49 cases each) to receive metoprolol alone and metoprolol combined with potassium magnesium aspartate,respectively.The course of treatment was one month.The clinical effect and dynamic electrocardiogram were compared,and the cardiac function index and arrhythmia index of patients before and after treatment were compared between the two groups.Results The clinical total effective rate of the observation group (95.92%) was significantly higher than that of the control group (81.63%) after treatment.The total effective rate of dynamic electrocardiogram in the observation group was 91.84%,which was significantly higher than 83.67% in the control group (P<0.05). After treatment,the left ventricular end-systolic diameter of the observation group was (44.78±6.42) mm,which was significantly lower than (50.58±6.83) mm of the control group.The cardiac output and left ventricular ejection fraction were (5.30±0.97) L/min and (41.29±8.56)%,respectively,which were significantly higher than (4.60±0.89) L/min and (31.86± 5.93)% of the control group (P<0.05).After treatment,the decreasing of number in atrial premature beat,ventricular premature beat,and junctional premature beat in the observation group were (1 621±354) times/24 h,(1 291±109) times/24 h,(117±34) times/ 24 h,which were significantly higher than (3 200±457)/24 h,(2 469±360)/24 h,(262±46) times/24 h in the control group (P<0.05).Conclusion Metoprolol combined with potassium magnesium aspartate in the treatment of elderly patients with ischemic arrhythmia is beneficial to improve the heart f
作者
李晓娥
郭伦锋
王妍妍
LI Xiao-e;GUO Lun-feng;WANG Yan-yan(Department of Pharmacy,Ankang Central Hospital,Ankang 725000,Shaanxi,CHINA;Department of Cardiology,Ankang Central Hospital,Ankang 725000,Shaanxi,CHINA)
出处
《海南医学》
CAS
2019年第8期963-966,共4页
Hainan Medical Journal
关键词
美托洛尔
门冬氨酸钾镁盐
缺血性心律失常
临床疗效
心功能
Metoprolol
Potassium magnesium aspartate
Ischemic arrhythmia
Clinical efficacy
Cardiac function
