摘要
闭塞性细支气管炎(bronchiolitis obliterans,BO)是一种小气道炎性损伤所致的慢性气流受限综合征,病理主要表现为细支气管管腔部分或完全闭塞。BO根据不同的病理表现类型可分为限制性细支气管炎和增殖性细支气管炎。良好的动物模型有助于阐明BO发病机制和探索新治疗方案;不同造模方法所建立的BO动物模型均拥有各自的优势和局限性。本文就BO非移植动物模型的相关研究进展进行综述。
Bronchiolitis obliterans (BO) is a clinical syndrome characterized by chronic obstruction of the bronchioles.Pathologically,BO is characterized by partial or complete occlusion of the bronchioles.Pathological types include constrictive bronchiolitis and proliferative bronchiolitis.Ideal animal models have contributed to characterizing the pathogenesis of BO and exploring new therapeutic schedules.Animal models of BO have been established by different methods.These models each have their own advantages and limitations.This article reviews the recent progress in research on animals models of nontransplant BO.
作者
张抗抗
陈德晖
ZHANG Kangkang;CHEN Dehui(Guangzhou Medical University,Guangzhou 510120,China;Department of Pediatrics,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第4期114-119,共6页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金(81770063)
广东省社会发展领域科技计划项目(2014A020212356)
广州市科技创新项目(201504281719217)
呼吸疾病国家重点实验室开放课题(SKLRD20160P005)
关键词
闭塞性细支气管炎
非移植
动物模型
bronchiolitis obliterans
nontransplantation
animal model
