摘要
目的观察右美托咪定术前滴鼻在小儿麻醉中的临床效果。方法选取四川省人民医院温江分院2014年4月至2017年4月行包皮环切术患儿40例为研究对象,ASAⅠ级,年龄范围2~10岁,采用随机数字表法分为两组,术前30min分别经鼻腔予右美托咪定1μg/kg(实验组)和等容量0.9%氯化钠注射液(对照组)。记录给药前(T0)、滴鼻后5min(T1)、滴鼻后10min(T2)、滴鼻后20min(T3)、滴鼻后30min(T4)患儿心率、血氧饱和度、血压,给药30min后评估患儿镇静评分,观察并记录术后清醒时的躁动评分。结果重复测量方差分析结果显示:组间因素中,SBP(F=14.54、P<0.05)和DBP(F=22.69、P<0.05)差异有统计学意义;组内因素中SBP(F=13.77、P<0.05)、DBP(F=10.48、P<0.05)和HR(F=5.13、P<0.05)存在交互作用,差异有统计学意义。与对照组相比,实验组各时间点心率、血压均低于对照组(P<0.05),镇静评分优于对照组(t=-9.131,P<0.05),术后躁动评分低于对照组(t=3.387,P<0.05)。结论右美托咪定术前滴鼻能提供满意的镇静效果,不影响患儿的生命体征,并且显著降低全麻术后躁动的发生。
Objective To observe the clinical effects of preoperative intranasal dexmedetomidine in pediatric anesthesia.MethodsFrom April 2014 to April 2017,40 pediatric patients who accepted elective circumcision,ASAⅠ,aged 2 to 10 years in Wenjiang Branch of Sichan Provincial People's Hospital were divided into two groups,with 20 cases in each group.The test group received intranasal dexmedetomidine 1μg/kg,and the control group received intranasal equal volume of saline 30 min before surgery.HR,SpO2,BP were monitored and recorded before intranasal(T0),5min after intranasal(T1),10min after intranasal(T2),20min after intranasal(T3),30min after intranasal(T4).The sedation score was assessed after 30 min of administration.The restless score was observed after waking.ResultsANOVA analysis showed that there were significant differences in SBP(F=14.54,P<0.05)and DBP(F=22.69,P<0.05)between the two groups,and the SBP(F=13.77,P<0.05),DBP(F=10.48,P<0.05),HR(F=5.13,P<0.05)had interaction effects.Compared with those of the control group,the heart rate and the diastolic pressure of the test group were decreased at T2~T4(all P<0.05).The sedation score of the test group was superior than that of the control group(t=-9.131,P<0.05),and the postoperative agitation score was lower than that of the control group(t=3.387,P<0.05).ConclusionIntranasal dexmedetomidine can provide satisfactory sedative effects without affecting the vital signs of children and significantly reducing the postoperative agitation.
作者
李解
胡晓娟
王梓仲
唐杰
许柳
王飞
Li Jie;Hu Xiaojuan;Wang Zizhong;Tang Jie;Xu Liu;Wang Fei(Department of Anesthesiology,Wenjiang Branch of Sichan,Provincial People's Hospital,Chengdu,Sichuan 611130,China;Department of Pharmacy,Wenjiang Branch of Sichan Provincial People's Hospital,Chengdu,Sichuan 611130,China;Department of Pharmacy,the Maternal and Child Health Hospital of Ningxia Hui Autonomous Region,Yinchuan,Ningxia 750004,China)
出处
《中国基层医药》
CAS
2019年第3期261-263,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
四川省成都市卫计委科研项目(150043/2015100).
关键词
右美托咪定
滴鼻
小儿麻醉
术前
包皮环切术
Dexmedetomidine
Intranasal
Pediatric anesthesia
Preoperative
Circumcision
