摘要
目的探究联合抗干燥综合征抗原A(SSA)抗体、抗干燥综合征抗原B(SSB)抗体、抗核抗体(ANA以及抗环胍氨酸肽(CCP)抗体对诊断原发性干燥综合征的临床意义。方法选取东莞市人民医院2015年1月～2017年12月收治疑似干燥综合征患者239例作为研究对象,所有患者均行抗体SSA/Ro60kD、SSA/Ro52KD、SSB/La、ANA以及抗环瓜氨酸肽抗体检测,所有研究对象按最后确诊情况分为患病组(n=105)与未患病组(n=134),比较两组SSA/Ro60kD、SSA/Ro52KD、SSB/La、ANA以及抗环瓜氨酸肽抗体阳性率及患病组敏感度及特异度。结果抗体SSA/Ro60kD、SSA/Ro52KD、SSB/La、ANA以及抗环瓜氨酸肽抗体在患病组患者中的阳性率分别为46.67%、44.76%、16.19%、85.71%及11.43%,未患病组患者的阳性率分别为23.13%、16.42%、5.22%、91.79%及8.96%,患病组SSA/Ro60kD、SSA/Ro52KD、SSB/La检出阳性率较未患病组高,差异有统计学意义(P <0.05);患病组联合检测阳性病例为94例,阳性率89.52%,敏感度89.52%,特异度90.30%;未患病组联合检测阳性病例为13例,阳性率9.70%,两组联合检测阳性率相比,差异有统计学意义(χ~2=151.699,P=0.000)。结论抗体SSA/Ro60kD、SSA/Ro52KD、SSB/La、ANA以及抗环瓜氨酸肽抗体联合检测,可提高对原发性干燥综合征的诊断敏感度,同时联合检测抗体在原发性干燥综合的特异度亦较高,具有较好的临床应用价值。
Objective To explore the diagnostic value of anti-sjogren's syndrome antigen A (SSA),anti-sjogren's syndrome antigen B (SSB),anti-nuclear antibody (ANA) and anti-cyclic guanidine peptide (CCP) antibodies in primary dry syndrome. Methods 239 suspected sjogren's syndrome patients admitted to Dongguan People's Hospital from January 2015 to December 2017 were selected as subjects.All patients were tested for antibodies to SSA/ Ro60kD,SSA/Ro52KD,SSB/La,ANA and anti-cyclic citrullinated peptide antibodies, and were divided into the sick group(n=105) and the non-sick group(n=134) according to the final diagnosis.The positive rates of SSA/Ro60kD,SSA/ Ro52KD,SSB/La,ANA and anti-cyclic citrullinated peptide antibodies and the sensitivity and specificity of the two groups were compared. Results The positive rates of antibody SSA/Ro60kD,SSA/Ro52KD,SSB/La,ANA and anticyclic citrullinated peptide antibody were 46.67%,44.76%,16.19%,85.71% and 11.43%,respectively in the sick group,the positive rates of patients in the non-sick group were 23.13%,16.42%,5.22%,91.79% and 8.96%,respectively. The positive rate of SSA/Ro60kD,SSA/Ro52KD and SSB/La in the sick group was higher than that in the non-sick group,and the difference was statistically significant (P<0.05).There were 94 positive cases in the sick group with positive rate,sensitivity and specificity of 89.52%,89.52% and 90.30%,respectively,and there were 13 cases in the non-sick group with positive rate of 9.70%.Compared with the combined detection positive rate of the two groups,the difference was statistically significant (χ^2=151.699,P=0.000). Conclusion The combined detection of antibody SSA/ Ro60kD,SSA/Ro52KD,SSB/La,ANA and anti cyclic citrullinated peptide antibody can improve the sensitivity to the diagnosis of primary Sjogren syndrome,and the specificity of the combined detection of antibody in primary drying is also high,which is of good clinical value.
作者
温丽娴
高敏
林城
张世豪
WEN Lixian;GAO Min;LIN Cheng;ZHANG Shihao(Clinical Lab,Dongguan Shipai Hospital,Dongguan 523330,China;Department of Pathology,Dongguan People's Hospital,Dongguan 523059,China)
出处
《中国医药科学》
2019年第5期183-185,189,共4页
China Medicine And Pharmacy
关键词
原发性干燥综合征
抗环胍氨酸肽抗体
抗核抗体
诊断价值
Primary sjogren's syndrome
Anti cyclic guanidine peptide antibody
Antinuclear antibody
Diagnostic value
