摘要
目的探讨红细胞分布宽度(RDW)和单核细胞/淋巴细胞(MLR)比值在干燥综合征(SS)诊断中的临床应用价值。方法收集南京医科大学附属鼓楼医院2020年1月-2020年9月收治的96例SS患者作为SS组,另选取同期于南京医科大学附属鼓楼医院健康管理中心定期体检的100例健康人群作为健康对照组。比较SS组与健康对照组各个实验室检测指标的差异,再对不同活动度下RDW、MLR进行比较,评估SS组中RDW、MLR在ESR、CRP、补体、免疫球蛋白(Ig)界定的阴阳性患者间的差异。采用Spearman秩相关分析SS患者RDW、MLR与其他指标的关系,二元Logistic分析、ROC曲线研究RDW、MLR对SS的诊断价值。结果与健康对照组相比,SS患者RDW、MLR均显著升高(P=0.001),RDW在稳定组和活动组之间有显著差异(P=0.007),且在ESR、补体、Ig界定的阴阳性患者间的差异有统计学意义(P<0.05),MLR在CRP界定的阴阳性患者间的差异有统计学意义(P<0.05)。RDW与ESR、CRP、IgG呈正相关,与L、PLT、HCT、C3、C4呈负相关,MLR仅与ESR呈正相关。ROC曲线表明,RDW、MLR均为较佳诊断指标,AUC分别为0.767、0.760。结论 RDW、MLR作为简单易得的生物学指标,在SS诊断中可作为辅助检测指标,对与其他指标的联合性分析具有重要的价值。
Objective To explore the clinical application value of red blood cell distribution width(RDW)and monocyte/lymphocyte(MLR)ratio in the diagnosis of Sjogren’s syndrome(SS).Methods A total of 96 patients with SS in Nanjing Gulou Hospital from January 2020 to September 2020 were selected as SS group,and 100 healthy people in health management center of Nanjing Gulou Hospital during the same period were selected as healthy control group.The differences of each laboratory test indicators between SS group and healthy control group were compared,and then RDW and MLR under different activity levels were compared,The differences of RDW and MLR between the negative and positive patients defined by ESR,CRP,complement and Ig in SS group were evaluated.Spearman rank correlation analysis was used to analyze the relationship between RDW,MLR and other indicators in SS patients.Binary logistic analysis and ROC curve were used to study the diagnostic value of RDW and MLR in SS.Results Compared with healthy control group,RDW and MLR of SS patients were significantly increased(P=0.001),RDW was significantly different between stable group and active group(P=0.007),And the differences of RDW between the negative and positive patients defined by ESR,CRP,complement and Ig in SS group were statistical significance(P<0.05).MLR was significantly different between the negative and positive patients defined by CRP(P<0.05).RDW was positively correlated with ESR,CRP and IgG,negatively correlated with lymphocyte,PLT,HCT,C3 and C4,while MLR was only positively correlated with ESR.ROC curve shows that RDW and MLR were better diagnostic indicators,and AUC were0.767 and 0.760 respectively.Conclusion RDW and MLR,as simple and easily obtain biological indicators,can be used as auxiliary detection indicators in the diagnosis of SS,and have important value in the combination analysis with other indicators.
作者
冯家维
贾佳
黄爱军
沈瀚
FENG Jia-wei;JIA Jia;HUANG Ai-jun(Department of Laboratory,Nanjing Durm Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing 210000,China)
出处
《中国实验诊断学》
2021年第6期844-848,共5页
Chinese Journal of Laboratory Diagnosis
