摘要
目的研究玄参Scropularia ningpoensis Hemsl.的化学成分。方法玄参80%甲醇提取物采用硅胶和Sephadex LH-20进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中分离得到13个化合物,分别鉴定为对羟基肉桂酸甲酯(1)、3, 4-二甲氧基肉桂酸(2)、对羟基苯甲醛(3)、3-羟基对甲氧基苯甲醛(4)、对羟基苯乙酮(5)、肉桂酸(6)、2-(3′,4′-二羟基苯基)-1,3-苯并二茂恶-5-甲醛(7)、3-羟基对甲氧基苯甲酸(8)、对羟基肉桂酸(9)、阿魏酸(10)、3-甲氧基对羟基肉桂醛(11)、对羟基苯乙醇(12)、5-羟甲基糠醛(13)。结论化合物2、4、7～8、11～12为首次从该植物中分离得到。
AIM To study the chemical constituents from Scropularia ningpoensis Hemsl.. METHODS The 80% methanol extract from S. ningpoensis was isolated and purified by silica and Sephadex LH-20, then the structures of obtained compounds were identified by physicochemical properties and spectral data. RESULTS Thirteen compounds were isolated and identified as methyl p-hydroxycinnamate (1), 3, 4-dimethoxycinnamic acid (2), p-hydroxybenzaldehyde (3 ), 3-hydroxy-p-methoxybenzaldehyde (4 ), p-hydroxyacetophenone ( 5 ), cinnamic acid ( 6 ), 2-( 3′, 4′-dihydroxyphenyl )-1, 3-benzodioxole-5-carboxaldehyde ( 7 ), 3-hydroxy-pmethoxybenzoic acid (8), p-hydroxycinnamic acid (9), ferulic acid (10), 3-methoxy-p-hydroxycinnamaldehyde (11), p-hydroxyphenethyl alcohol (12), 5-(hydroxymethyl)-furfura (13). CONCLUSION Compounds 2, 4, 7-8 and 11-12 are isolated from this plant for the first time.
作者
刘年珍
赵碧清
钱群刚
陈乃宏
周小江
LIU Nian-zhen;ZHAO Bi-qing;QIAN Qun-gang;CHEN Nai-hong;ZHOU Xiao-jiang(Hunan University of Chinese Medicine,Changsha 410208,China;Standardization and Functional Engineering Technology Research Center of Traditional Chinese Medicine Pieces in Hunan Province,Changsha 410208,China)
出处
《中成药》
CAS
CSCD
北大核心
2019年第3期576-579,共4页
Chinese Traditional Patent Medicine
基金
国家中医药管理局玄参等2种中药饮片标准化建设项目(ZYBZH-Y-HUN-24)
湖南省重点研发计划项目(2017NK2261)
长沙市科技局科技计划项目(kq1701068)
关键词
玄参
化学成分
分离鉴定
Scropularia ningpoensis Hemsl.
chemical constituents
isolation and identification
