摘要
目的对毛相思子(Abrus mollis Hance)的化学成分进行系统研究,明确其物质基础。方法利用反复硅胶柱色谱法、开放ODS柱色谱法、Sephadex LH-20柱色谱法以及高效液相色谱法等方法,对毛相思子70%乙醇提取物的二氯甲烷和乙酸乙酯萃取部位进行分离,并根据化合物波谱数据进行结构确证。结果从毛相思子70%乙醇提取物中共分离得到5个黄酮类化合物和9个酚酸类化合物,分别为2α,3α-环氧-5,7,3′,4′-四羟基黄烷-(4β-8-表儿茶素)(1)、epicatechin-[8,7-e]-4β-(4-hydroxyphenyl)-dihydro-2(3H)-pyranone(2)、(±)-墨沙酮(3)、7-羟基-4′-甲氧基二氢黄酮(4)、2S-甘草素(5)、N-p-hydroxy-trans-coumaroyltyramine(6)、N-p-hydroxy-cis-coumaroyltyramine(7)、N-[4′-羟基-(E)-肉桂酰基]-L-色氨酸甲酯(8)、N-[4′-羟基-(Z)-肉桂酰基]-L-色氨酸甲酯(9)、阿魏酸甲酯(10)、3,5-二甲氧基-4-羟基苯乙酮(11)、香草酸甲酯(12)、反式香豆酸甲酯(13)、乙酰香草酮(14)。结论化合物1~4和6~9均为首次从相思子属植物中分离得到,化合物5、10~14为首次从毛相思子中分离得到。
In this paper,the chemical constituents of Abrus mollis Hance were systematically studied.Five flavonoids and nine phenolic acids were isolated from CH2Cl2 and EtOAc fraction of 70%EtOH extracts from A.mollis by the means of column chromatography and preparative-HPLC,etc.The structures were identified as 2α,3α-epoxy-5,7,3′,4′-tetrahydroxyflavan-(4β-8-epicatechin)(1),epicatechin-[8,7-e]-4β-(4-hydroxyphenyl)-dihydro-2(3H)-pyranone(2),(±)-maesopsin(3),7-hydroxy-4′-methoxy dihydroflavone(4),2S-liquirtigenin(5),N-p-hydroxy-trans-coumaroyltyramine(6),N-p-hydroxy-ciscoumaroyltyramine(7),N-[4′-hydroxy-(E)-cinnamoyl]-L-tryptophan methyl ester(8),N-[4′-hydroxy-(Z)-cinnamoyl]-L-tryptophan methyl ester(9),methyl feruate(10),3,5-dimethoxy-4-hydroxyacetophenone(11),methyl vanillate(12),trans-coumaric acid methyl ester(13),and acetovanillone(14)based on the spectral data analyses,physicochemical properties and comparison with reported compounds.Compounds 1-4 and 6-9 were isolated from Abrus genus for the first time,while compounds 5 and 10-14 were firstly obtained from A.mollis.
作者
陈亮
李国昌
张彩萍
鞠艳
梁惠
杜开成
汪雨濛
孟大利
CHEN Liang;LI Guochang;ZHANG Caiping;JU Yan;LIANG Hui;DU Kaicheng;WANG Yumeng;MENG Dali(Department of Natural Medicinal Chemistry,School of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China)
出处
《中国药物化学杂志》
CAS
2024年第3期188-194,共7页
Chinese Journal of Medicinal Chemistry
基金
国家自然科学基金面上项目(81573694)
关键词
毛相思子
黄酮
酚酸
Abrus mollis Hance
flavonoid
phenolic acid
