摘要
目的探讨血液净化联合重组促红细胞生成素(EPO)治疗对尿毒症患者骨代谢的影响。方法 96例尿毒症患者随机分为观察组(n=48)与对照组(n=48),对照组给予血液净化治疗,观察组给予血液净化联合重组EPO治疗,均治疗观察4 w。结果所有患者都顺利完成治疗,治疗过程中血压、心率等生命体征均正常;观察组的总有效率高于对照组(P <0.05);治疗后,两组血清骨保护素(OPG)、kB受体活化子配体(RANKL)、血尿素氮(BUN)与肌醇(Cr)含量均低于治疗前,且观察组明显低于对照组(P <0.05)。结论血液净化联合重组EPO治疗尿毒症能改善患者骨代谢异常和肾损伤,从而提高治疗效果。
Objective To explore the effects of blood purification combined with recombinant erythropoietin(EPO)on bone metabolism in patients with uremia.MeAods A total of 96 patients with uremia wee randomly divided into an observation group and a control group(n=48,respectively).The control group was treated with blood purification,while the obsersation group was treated with blood purification combined with recombinant EPO.All patients were treated for four weeks.Results All patients completed the treatment successfully,and the blood pressure,heart rate and other vital signs were normal during the treatment,and the total effective rate of the observation group was higher than that of the control group(P<0.05).After the treatment,the serum levels of osteoprotegerin(OPG),kB receptor activator ligand(RANKL),blood urea nitrogen(BUN)and inositol(Cr)of the two groups were lower than those before the treatment,and those in the observation group were significantly lower than those in the control group(P<0.05).Conclusion Blood purification combined with recombinant EPO can improve bone metabolism and kidney injury in uremia patients,so as to improve the therapeutic effects.
作者
邓湘佐
高利丽
宋晓平
杨晓松
赵丽华
Zhao Lihua;Gao Lili;Song Xiaoping;Yang Xiaosong;Zhao Lihua(Department of Blood Purification,General Hospital of Liaohe Oilfield,Panjin,Liaoning,124010,China;Department of Nephrology,The First Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning,121001,China)
出处
《西南国防医药》
CAS
2019年第3期326-328,共3页
Medical Journal of National Defending Forces in Southwest China
