摘要
目的:本研究通过检测结肠癌组织中TRPC6的表达,探讨其在结肠癌发生、发展中的作用和临床意义。方法:以免疫组织化学法检测60例结肠癌组织和30例癌旁组织的TRPC6的表达,比较结肠癌组织和癌旁组织,以及结肠癌临床分期和病理组织学分型之间TRPC6表达差异。结果:TRPC6在结肠癌组织中(-)占23.3%(14/60),(+)占41.7%(25/60),(++)占26.7%(16/60),(+++)占8.3%(5/60);在对照组中(-)占43.3%(13/30),(+)占50.0%(15/30),(++)占6.7%(2/30),(+++)占0(0/30)。两组相比,结肠癌组的TRPC6表达水平显著高于对照组(P <0.05)。并且TRPC6表达水平与结肠癌的临床分期、病理组织学分型无关。结论:TRPC6作为结肠癌诊断的分子靶标还不充分,但作为治疗靶点有一定的意义。
Objective:To reveal the potential role of transient receptor potential channel 6 (TRPC6) in colon cancer. Methods:To study the expression of TRPC6 in colon cancer tissues.60 colon cancer patients were enrolled in this study,and 30 adjacent tissues (cancer tissue edge ≥5 cm) as control group.The expression of TRPC6 was analyzed by immunohistochemical staining. Results:Among 60 colon cancer tissues,TRPC6 expression rate was (-) 23.3%(14/60),(+) 41.7%(25/60),(++) 26.7%(16/60),and (+++) 8.3%(5/60) respectively.Among 30 adjacent tissues,TRPC6 expression rate was (-) 43.3%(13/30),(+) 50.0%(15/30),(++) 6.7%(2/30),and (+++) 0(0/30).TRPC6 expression in colon cancer tissues was significant higher than that in adjacent tissues ( P <0.05).In addition,the level of TRPC6 expression in colon cancer tissues was irrelevant with clinical stages and pathological differentiation. Conclusion:TRPC6 can' t be confirmed as target for diagnosis of colon cancer by the current data.But this finding provides a new therapeutic strategy for colon cancer.
作者
胡炜
耿玲
Hu Wei;Geng Ling(Oncology Department,Jinzhou Central Hospital,Liaoning Jinzhou 121001,China;Pathology Department,Jinzhou Central Hospital,Liaoning Jinzhou 121001,China)
出处
《现代肿瘤医学》
CAS
2019年第6期1002-1005,共4页
Journal of Modern Oncology
基金
辽宁省自然科学基金项目(编号:201602269)
关键词
TRPC6
结肠癌
临床分期
病理组织学分型
transient receptor potential channel 6
colon cancer
clinical stages
pathological differentiation
