摘要
目的观察高压氧治疗老年轻度认知功能障碍(MCI)的效果。方法回顾性分析60例MCI老年患者,按照治疗方式的不同分为B组和A组,各30例。A组给予奥拉西坦和多奈哌齐治疗,B组在A组基础上,加用高压氧治疗。治疗前和治疗3 w后,采用简易智能状态评定量表(MMSE)和蒙特利尔认知评估量表(MoCA)评定患者认知功能,采用日常生活能力(ADL)量表评定患者日常生活能力,比较两组治疗前后认知功能和日常生活能力变化以及不良反应发生情况。结果治疗后,两组的MMSE和MoCA评分均升高,ADL评分均下降,且B组的MMSE和MoCA评分均明显高于A组,ADL评分明显低于A组(P <0.05)。两组治疗前后肝肾功能、心脑电图及血尿常规指标均在正常范围内,A组不良反应发生率(16.66%)高于B组(6.67%),但差异无统计学意义(P> 0.05)。结论高压氧联合奥拉西坦和多奈哌齐治疗老年MCI临床效果显著,可明显改善患者认知功能和日常生活能力,且安全性高,值得临床推广应用。
Objective To observe the effect of hyperbaric oxygen on mild cognitive impairment(MCI)in senile patients.Methods The data of 60 senile patients with MCI were retrospectively analyzed.They were divided into group A and group B according to different therapies(n=30,respectively).Group A was treated with oxiracetam and donepezil.Group B was treated with hyperbaric oxygen on the basis of group A.Before the treatment and three weeks after the treatment,the cognitive function was assessed by MMSE and MoCA,and ability of daily living was assessed by ADL chart.The changes of cognitive function,ability of daily living and adverse reactions were compared between the two groups before and after the treatment.Results After the treatment,the scores of MMSE and MoCA increased and ADL decreased in both groups.The scores of MMSE and MoCA in group B were significantly higher than those in group A,and the ADL scores were significantly lower than those in group A(P<0.05).The liver and kidney functions,electrocardiogram(ECG)and routine indexes of hematuria in both groups before and after treatment were within the normal range.The incidence of adverse reactions in group A(16.66%)was higher than that in group B(6.67%),but there was no significant difference(P>0.05).Conclusion Hyperbaric oxygen combined with oxiracetam and donepezil in the treatment of MCI in senile patients has significant clinical effects,can significantly improve cognitive functions and the ability of daily living of patients,and has high safety;it is worthy of clinical application.
作者
曾金明
徐伟建
Zeng Jinming;Xu Weijian(Rehabilitation Department,MCC Shanghai Hospital,Shanghai,201901,China)
出处
《西南国防医药》
CAS
2019年第1期36-38,共3页
Medical Journal of National Defending Forces in Southwest China
关键词
认知功能障碍
高压氧
老年
轻度
认知功能
日常生活能力
cognitive impairment
hyperbaric oxygen
senile
mild
cognitive function
ability of daily living
