摘要
目的研究子宫内膜异位症(即EMS)合并不孕妇女内分泌的临床治疗,以及观察患者血清中内分泌激素的水平以及患者自身的免疫抗体情况。方法选取2017年1—12月该院体检孕妇127例,利用化学免疫荧光法这一检测技术进行检测。将检测的样本分为4组,分别是对照组(健康的待孕妇女)30个样本、1组(只不孕的妇女)32个样本、2组(只子宫内膜异位症)35个样本、3组(EMS合并不孕)30个样本。通过测定她们血液中抗绒毛促性腺激素抗体(HCGAb)、胰岛素(INS)、卵泡刺激素(FSH)、雌二醇(E2)、睾酮(T)、黄体生成素(LH)、泌乳素(PRL)水平,并通过ELISA酶联免疫法检查各测试小组的抗卵巢抗体(AOAb)、抗精子抗体(ASAb)、抗心磷脂抗体(ACAb)、抗子宫内膜抗体(EMAb)四种抗体的阳性情况。结果第3组样本中T、E2、PRL、INS 4种激素水平分别为(2.1±1.1)ng/mL、(139±78)pg/mL、(49±12)ng/mL、(9.8±2.7)μU/mL,明显比其他各组激素水平高,且差异有统计学意义(P<0.05),而LH、FSH这两种激素的水平差异无统计学意义(P>0.05),第2组样本中PRL的水平为(38±10)ng/mL,比第1组和对照组都要高,差异有统计学意义(P<0.05),另外几种激素水平差异无统计学意义(P>0.05)。第3组的阳性反应率为63.3%,比其他3组明显要高(P<0.05),2组及1组的样本抗体阳性率差异无统计学意义(P>0.05)。结论 EMS不孕的病因可能是由于EM患者自身免疫失调导致的E2、PRL、T激素分泌异常。
Objective To study the clinical treatment of endocrine of delivery women with endometriosis combined with infertility in order to observe the endocrine hormone level in serum and immune antibody of patients. Methods 127 cases of delivery women for physical examination in our hospital from January to December 2017 were selected, and tested by the immunofluorescence method, and the samples were divided into four groups, respectively 30 samples in the control group (healthy women to be pregnant , 32 samples in the group 1 (only infertility women)in the group 1, 35 samples (only endometriosis), 30 samples in the group 3 (EMS combined with infertility), and the HCGAb, INS, FSH, E2, T, LH, PRL levels in the blood were measures, and the positive conditions of AOAb, ASAb, ACAb, EMAb of various test groups were tested by the ELISA euzymelinked immunosorbent assay. Results The T, E2, PRL, INS levels in the group 3 were respectively (2.1±1.1)ng/mL,(139±78)pg/mL,(49±12)ng/mL,(9.8±2.7)μU/mL, which were obviously higher than those in the other hormone levels, and the differences were statistically significant(P<0.05), but the differences in the LH and FSH levels between the two groups were not statistically significant(P>0.05), and the PRL level in the group 2 was(38±10)ng/mL, which was higher than that in the group 1 and in the control group, and the differences were statistically significant(P<0.05), besides, the differences in various hormone levels between groups were not statistically significant(P>0.05), and the positive reactive rate in the group 3 was 63.3%, which was obviously higher than that in the other three groups(P<0.05,)and the difference in the positive rate of antibody between the group 2 and group 1 was not statistically significant(P>0.05). Conclusion The EMS infertility can be caused by the abnormal secretion of E2, PRL and T of immune dysregulation of EM patients.
作者
钟晓阳
朱恩恩
范丽静
ZHONG Xiao-yang;ZHU En-en;FAN Li-jing(Department of Gynecology,Meifeng Pengpai Memorial Hospital of Shanwei,Shanwei,Guangdong Province,516400 China)
出处
《系统医学》
2018年第22期117-119,共3页
Systems Medicine
